Gene Symbol: kin-10
Description: Casein kinase II subunit beta
Alias: Casein kinase II subunit beta
Species: Caenorhabditis elegans
Hu J, Bae Y, Knobel K, Barr M. Casein kinase II and calcineurin modulate TRPP function and ciliary localization. Mol Biol Cell. 2006;17:2200-11 pubmed
..A dynamic phosphorylation-dephosphorylation cycle may represent a mechanism for modulating TRPP activity, cellular sensation, and ciliary protein localization. ..
Popovici C, Berda Y, Conchonaud F, Harbis A, Birnbaum D, Roubin R. Direct and heterologous approaches to identify the LET-756/FGF interactome. BMC Genomics. 2006;7:105 pubmed
..The interactors identified play various roles in developmental process or basic biochemical events such as ribosome biogenesis. ..
Wang X, Gupta P, Fairbanks J, Hansen D. Protein kinase CK2 both promotes robust proliferation and inhibits the proliferative fate in the C. elegans germ line. Dev Biol. 2014;392:26-41 pubmed publisher
..differentiation decision. This eventually causes a shift towards the proliferative fate in the stem cell fate decision. ..
Matthews L, Vaglio P, Reboul J, Ge H, Davis B, Garrels J, et al
. Identification of potential interaction networks using sequence-based searches for conserved protein-protein interactions or "interologs". Genome Res. 2001;11:2120-6 pubmed
..However, the generation of such maps is costly and labor intensive. Here, we investigate the extent to which a protein interaction map generated in one species can be used to predict interactions in another species. ..
Medley J, Kabara M, Stubenvoll M, DeMeyer L, Song M. Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos. Biol Open. 2017;6:17-28 pubmed publisher
..Our data suggest that CK2 functions in cell division and negatively regulates centrosome duplication in a kinase-dependent manner. ..
Park J, Lee J, Park J, Kim D, Hahm J, Nam H, et al
. Downregulation of protein kinase CK2 activity induces age-related biomarkers in C. elegans. Oncotarget. 2017;8:36950-36963 pubmed publisher
..Therefore, the present results suggest that age-dependent CK2 downregulation reduces longevity by associating with both ROS generation and the AGE-1-AKT-1-DAF-16 pathway in C. elegans. ..
Alessi A, Khivansara V, Han T, Freeberg M, Moresco J, Tu P, et al
. Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1. Proc Natl Acad Sci U S A. 2015;112:E7213-22 pubmed publisher
..Importantly, we identify the conserved DEAD-box RNA helicase, CGH-1/DDX6, as a key CK2 substrate within miRISC and demonstrate phosphorylation of a conserved N-terminal serine is required for CGH-1 function in the miRNA pathway. ..