Gene Symbol: kgb-1
Description: GLH-binding kinase 1
Alias: GLH-binding kinase 1
Species: Caenorhabditis elegans

Top Publications

  1. Smith P, Leung Chiu W, Montgomery R, Orsborn A, Kuznicki K, Gressman Coberly E, et al. The GLH proteins, Caenorhabditis elegans P granule components, associate with CSN-5 and KGB-1, proteins necessary for fertility, and with ZYX-1, a predicted cytoskeletal protein. Dev Biol. 2002;251:333-47 pubmed
    ..Similar to the loss of GLH-1 and GLH-4, loss of either CSN-5 or KGB-1 causes oogenesis to cease, but does not affect the initial assembly of P granules. ..
  2. Mizuno T, Hisamoto N, Terada T, Kondo T, Adachi M, Nishida E, et al. The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. EMBO J. 2004;23:2226-34 pubmed
    ..These results suggest that VHP-1 plays a pivotal role in the integration and fine-tuning of the stress response regulated by the KGB-1 MAPK pathway. ..
  3. Mizuno T, Fujiki K, Sasakawa A, Hisamoto N, Matsumoto K. Role of the Caenorhabditis elegans Shc adaptor protein in the c-Jun N-terminal kinase signaling pathway. Mol Cell Biol. 2008;28:7041-9 pubmed publisher
    ..These results suggest that SHC-1 acts as a scaffold to link MAPKKK to MAPKK activation in the KGB-1 MAPK signal transduction pathway. ..
  4. Kao C, Los F, Huffman D, Wachi S, Kloft N, Husmann M, et al. Global functional analyses of cellular responses to pore-forming toxins. PLoS Pathog. 2011;7:e1001314 pubmed publisher
  5. Huffman D, Abrami L, Sasik R, Corbeil J, van der Goot F, Aroian R. Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins. Proc Natl Acad Sci U S A. 2004;101:10995-1000 pubmed
    ..Our data demonstrate that cells defend against pore-forming toxins by means of conserved MAPK pathways. ..
  6. Orsborn A, Li W, McEwen T, Mizuno T, Kuzmin E, Matsumoto K, et al. GLH-1, the C. elegans P granule protein, is controlled by the JNK KGB-1 and by the COP9 subunit CSN-5. Development. 2007;134:3383-92 pubmed
    ..In addition, both KGB-1 and CSN-5 bind Vasa, a Drosophila germ granule component; therefore, similar regulatory mechanisms might be conserved from worms to flies. ..
  7. Uno M, Honjoh S, Matsuda M, Hoshikawa H, Kishimoto S, Yamamoto T, et al. A fasting-responsive signaling pathway that extends life span in C. elegans. Cell Rep. 2013;3:79-91 pubmed publisher
    ..Our results thus identify a fasting-responsive KGB-1/AP-1 signaling pathway, which, together with DAF-16, causes transcriptional changes that mediate longevity, partly through regulating proteostasis. ..
  8. Pellegrino M, Nargund A, Kirienko N, Gillis R, Fiorese C, Haynes C. Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature. 2014;516:414-7 pubmed publisher
    ..We propose that ATFS-1 import efficiency and the UPR(mt) is a means to detect pathogens that target mitochondria and initiate a protective innate immune response. ..
  9. Zhang Z, Liu L, Twumasi Boateng K, Block D, Shapira M. FOS-1 functions as a transcriptional activator downstream of the C. elegans JNK homolog KGB-1. Cell Signal. 2017;30:1-8 pubmed publisher

More Information


  1. Pispa J, Palmén S, Holmberg C, Jantti J. C. elegans dss-1 is functionally conserved and required for oogenesis and larval growth. BMC Dev Biol. 2008;8:51 pubmed publisher
    ..In contrast to unicellular eukaryotes, the C. elegans dss-1 encodes an essential protein, which is required for embryogenesis, larval growth, and oogenesis, and which is functionally conserved with its yeast and human homologues. ..
  2. Twumasi Boateng K, Wang T, Tsai L, Lee K, Salehpour A, Bhat S, et al. An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan. Aging Cell. 2012;11:659-67 pubmed publisher
    ..Furthermore, the age-dependent reversal has intriguing implications for our understanding of aging...
  3. Hattori A, Mizuno T, Akamatsu M, Hisamoto N, Matsumoto K. The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex. PLoS Genet. 2013;9:e1003315 pubmed publisher
    ..This study describes the direct link from JNK signaling, Fos phosphorylation, and regulation of kreg gene transcription, which modulates the stress response in C. elegans...
  4. Gerke P, Keshet A, Mertenskötter A, Paul R. The JNK-like MAPK KGB-1 of Caenorhabditis elegans promotes reproduction, lifespan, and gene expressions for protein biosynthesis and germline homeostasis but interferes with hyperosmotic stress tolerance. Cell Physiol Biochem. 2014;34:1951-73 pubmed publisher
  5. Nix P, Hisamoto N, Matsumoto K, Bastiani M. Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways. Proc Natl Acad Sci U S A. 2011;108:10738-43 pubmed publisher
    ..These two MAPKs are coregulated by the E3 ubiquitin ligase RPM-1(Phr1) via targeted degradation of the MAPKKKs DLK-1 and MLK-1 and by the MAPK phosphatase VHP-1(MKP7), which negatively regulates both PMK-3(p38) and KGB-1(JNK). ..