Gene Symbol: kat-1
Description: Acetyl-CoA acetyltransferase homolog, mitochondrial
Alias: Acetyl-CoA acetyltransferase homolog, mitochondrial
Species: Caenorhabditis elegans

Top Publications

  1. Mak H, Nelson L, Basson M, Johnson C, Ruvkun G. Polygenic control of Caenorhabditis elegans fat storage. Nat Genet. 2006;38:363-8 pubmed
    ..This pathway also includes genes encoding intraflagellar transport proteins and cyclic nucleotide gated channels, demonstrating that C. elegans fat storage is under polygenic control. ..
  2. Berdichevsky A, Nedelcu S, Boulias K, Bishop N, Guarente L, Horvitz H. 3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1. Proc Natl Acad Sci U S A. 2010;107:18927-32 pubmed publisher
    ..Our findings suggest that defects in fatty acid oxidation can limit lifespan and accelerate aging in C. elegans and that kat-1-mediated fatty acid oxidation is crucial for overexpressed sir-2.1 to delay aging. ..
  3. Srinivasan S, Sadegh L, Elle I, Christensen A, Faergeman N, Ashrafi K. Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Cell Metab. 2008;7:533-44 pubmed publisher
    ..Moreover, obesity and thinness are not solely determined by feeding behavior. Rather, feeding behavior and fat metabolism are coordinated but independent responses of the nervous system to the perception of nutrient availability. ..
  4. Zhang Y, Zou X, Ding Y, Wang H, Wu X, Liang B. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. BMC Genomics. 2013;14:164 pubmed publisher
    ..This study provides the first systematic genomic insight into lipid metabolism in C. elegans, supporting the use of C. elegans as an increasingly prominent model in the study of metabolic diseases. ..