Gene Symbol: jnk-1
Description: Stress-activated protein kinase jnk-1
Alias: Stress-activated protein kinase jnk-1
Species: Caenorhabditis elegans
Products:     jnk-1

Top Publications

  1. Villanueva A, Lozano J, Morales A, Lin X, Deng X, Hengartner M, et al. jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans. EMBO J. 2001;20:5114-28 pubmed
    ..Our results delineate at least two different JNK pathways through jkk-1 and mek-1 in C.elegans, and define interaction between MKK7, but not MKK4, and JNK. ..
  2. Byrd D, Kawasaki M, Walcoff M, Hisamoto N, Matsumoto K, Jin Y. UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans. Neuron. 2001;32:787-800 pubmed
    ..Our results suggest that UNC-16 may regulate the localization of vesicular cargo by integrating JNK signaling and kinesin-1 transport. ..
  3. Tanaka Hino M, Sagasti A, Hisamoto N, Kawasaki M, Nakano S, Ninomiya Tsuji J, et al. SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans. EMBO Rep. 2002;3:56-62 pubmed
    ..Thus, the NSY-1-SEK-1-MAPK cascade is activated by Ca2+ signaling through CaMKII and establishes asymmetric cell fate decision during neuronal development. ..
  4. Wolf M, Nunes F, Henkel A, Heinick A, Paul R. The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness. J Cell Physiol. 2008;214:721-9 pubmed
    ..These results provide evidence of indirect interactions between neuronal MAPK and peripheral insulin-like signaling in response to environmental stimuli (temperature, H2O2). ..
  5. Hammarlund M, Nix P, Hauth L, Jorgensen E, Bastiani M. Axon regeneration requires a conserved MAP kinase pathway. Science. 2009;323:802-6 pubmed publisher
    ..We conclude that after axon injury, activation of this MAP kinase cascade is required to switch the mature neuron from an aplastic state to a state capable of growth. ..
  6. Negi H, Shukla A, Khan F, Pandey R. 3?-Hydroxy-urs-12-en-28-oic acid prolongs lifespan in C. elegans by modulating JNK-1. Biochem Biophys Res Commun. 2016;480:539-543 pubmed publisher
    ..11 kcalmol-1. UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacological interventions in the delineation of molecular targets for aging and associated pathologies. ..
  7. Oh S, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis R, Tissenbaum H. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A. 2005;102:4494-9 pubmed
    ..Our findings define an interaction between two well conserved proteins, JNK-1 and DAF-16, and provide a mechanism by which JNK regulates longevity and stress resistance. ..
  8. Marudhupandiyan S, Balamurugan K. Intrinsic JNK-MAPK pathway involvement requires daf-16-mediated immune response during Shigella flexneri infection in C. elegans. Immunol Res. 2017;65:609-621 pubmed publisher
    ..These findings suggest that JNK-MAPK is not the sole pathway that enhances the immunity of the host. Nonetheless, the IIS pathway bridges the JNK-MAPK pathway that influences in protecting the host in counter to the M9OT infection. ..
  9. Crawley O, Giles A, Desbois M, Kashyap S, Birnbaum R, Grill B. A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning. PLoS Genet. 2017;13:e1007095 pubmed publisher
    ..These findings indicate the MIG-15/JNK-1 pathway can restrict both glutamatergic synapse formation and short-term learning. ..

More Information


  1. Kawasaki M, Hisamoto N, Iino Y, Yamamoto M, Ninomiya Tsuji J, Matsumoto K. A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons. EMBO J. 1999;18:3604-15 pubmed
    ..Furthermore, ectopic expression of JKK-1 in type-D motor neurons is sufficient to rescue the movement defect. Thus, the C.elegans JNK pathway functions in type-D GABAergic motor neurons and thereby modulates coordinated locomotion. ..
  2. Mizuno T, Fujiki K, Sasakawa A, Hisamoto N, Matsumoto K. Role of the Caenorhabditis elegans Shc adaptor protein in the c-Jun N-terminal kinase signaling pathway. Mol Cell Biol. 2008;28:7041-9 pubmed publisher
    ..These results suggest that SHC-1 acts as a scaffold to link MAPKKK to MAPKK activation in the KGB-1 MAPK signal transduction pathway. ..
  3. Settivari R, Vanduyn N, Levora J, Nass R. The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism. Neurotoxicology. 2013;38:51-60 pubmed publisher