Gene Symbol: jac-1
Description: Juxtamembrane domain-Associated Catenin;Juxtamembrane domain-associated catenin
Alias: Juxtamembrane domain-Associated Catenin;Juxtamembrane domain-associated catenin
Species: Caenorhabditis elegans

Top Publications

  1. Pettitt J, Cox E, Broadbent I, Flett A, Hardin J. The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis. J Cell Biol. 2003;162:15-22 pubmed
    ..These results suggest that JAC-1 acts as a positive modulator of cadherin function in C. elegans. ..
  2. Klompstra D, Anderson D, Yeh J, Zilberman Y, Nance J. An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity. Nat Cell Biol. 2015;17:726-35 pubmed publisher
    ..Our findings identify an E-cadherin-mediated pathway that translates cell contacts into cortical polarity by directly recruiting a symmetry-breaking factor to the adjacent cortex. ..
  3. Callaci S, Morrison K, Shao X, Schuh A, Wang Y, Yates J, et al. Phosphoregulation of the C. elegans cadherin-catenin complex. Biochem J. 2015;472:339-52 pubmed publisher
    ..Collectively, our findings support a model in which distinct phosphorylation events contribute to rapid CCC assembly and disassembly, both of which are essential for morphogenetic rearrangements during development. ..