Gene Symbol: ins-1
Description: INSulin related
Alias: INSulin related
Species: Caenorhabditis elegans

Top Publications

  1. Hung W, Wang Y, Chitturi J, Zhen M. A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication. Development. 2014;141:1767-79 pubmed publisher
    ..Under adverse conditions, a switch in the agonistic-antagonistic ILP balance activates intestinal DAF-16, which commits animals to diapause. ..
  2. Pierce S, Costa M, Wisotzkey R, Devadhar S, Homburger S, Buchman A, et al. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 2001;15:672-86 pubmed
    ..Of five other ins genes tested, the only other one bearing a predicted C peptide also antagonizes daf-2 signaling, whereas four ins genes without a C peptide do not, indicating functional diversity within the ins family. ..
  3. Tomioka M, Adachi T, Suzuki H, Kunitomo H, Schafer W, Iino Y. The insulin/PI 3-kinase pathway regulates salt chemotaxis learning in Caenorhabditis elegans. Neuron. 2006;51:613-25 pubmed
    ..These results suggest that INS-1 secreted from AIA interneurons provides feedback to ASER to generate plasticity of chemotaxis. ..
  4. Karmacharya R, Sliwoski G, Lundy M, Suckow R, Cohen B, Buttner E. Clozapine interaction with phosphatidyl inositol 3-kinase (PI3K)/insulin-signaling pathway in Caenorhabditis elegans. Neuropsychopharmacology. 2009;34:1968-78 pubmed publisher
    ..elegans. As this pathway is conserved across species, the results may have implications for understanding the unique effects of clozapine in humans. ..
  5. Chen C, Bellier A, Kao C, Yang Y, Chen H, Los F, et al. WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans. PLoS ONE. 2010;5:e9494 pubmed publisher
    ..Taken together, our data suggest that WWP-1 and DAF-16 function in parallel within the fundamental DAF-2 insulin/IGF-1 signaling network to regulate fundamental cellular responses in C. elegans. ..
  6. Depuydt G, Xie F, Petyuk V, Shanmugam N, Smolders A, Dhondt I, et al. Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans. Mol Cell Proteomics. 2013;12:3624-39 pubmed publisher
  7. Oláhová M, Veal E. A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity. Aging Cell. 2015;14:558-68 pubmed publisher
    ..In addition, we reveal that the temperature-dependent prolongevity function of PRDX-2 is required for the extended lifespan associated with several pathways, including further reductions in IIS. ..