Gene Symbol: icp-1
Description: InCenP homolog
Alias: InCenP homolog
Species: Caenorhabditis elegans
Kaitna S, Mendoza M, Jantsch Plunger V, Glotzer M. Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis. Curr Biol. 2000;10:1172-81 pubmed
..We propose that this complex acts by promoting dissolution of sister chromatid cohesion and the assembly of the central spindle. ..
Oegema K, Desai A, Rybina S, Kirkham M, Hyman A. Functional analysis of kinetochore assembly in Caenorhabditis elegans. J Cell Biol. 2001;153:1209-26 pubmed
..Furthermore, kinetochore assembly and the recruitment of CeINCENP to chromosomes are independent. These results suggest distinct roles for the kinetochore and the chromosomal passengers in mitotic chromosome segregation. ..
Romano A, Guse A, Krascenicova I, Schnabel H, Schnabel R, Glotzer M. CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1. J Cell Biol. 2003;161:229-36 pubmed
..ICP-1 dramatically stimulates AIR-2 kinase activity. This activity is not stimulated by CSC-1/BIR-1, suggesting that these two subunits function as targeting subunits for AIR-2 kinase. ..
Cockell M, Baumer K, GONCZY P. lis-1 is required for dynein-dependent cell division processes in C. elegans embryos. J Cell Sci. 2004;117:4571-82 pubmed
..These results suggest that dynein and Lis1, albeit functioning in identical processes, are targeted partially independently of one another. ..
Bishop J, Han Z, Schumacher J. The Caenorhabditis elegans Aurora B kinase AIR-2 phosphorylates and is required for the localization of a BimC kinesin to meiotic and mitotic spindles. Mol Biol Cell. 2005;16:742-56 pubmed
..Together with our previous data, these results suggest that at least one function of the Aurora B kinases is to recruit spindle-associated motor proteins to their sites of action. ..
Han Z, Riefler G, Saam J, Mango S, Schumacher J. The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase. Curr Biol. 2005;15:894-904 pubmed