icl-1

Summary

Gene Symbol: icl-1
Description: Malate synthase
Alias: Malate synthase
Species: Caenorhabditis elegans

Top Publications

  1. Murphy C, McCarroll S, Bargmann C, Fraser A, Kamath R, Ahringer J, et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 2003;424:277-83 pubmed
  2. Yuan Y, Kadiyala C, Ching T, Hakimi P, Saha S, Xu H, et al. Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans. J Biol Chem. 2012;287:31414-26 pubmed publisher
    ..We conclude that an increase, not a decrease in fuel consumption, via an accelerated oxidation of fuels in the TCA cycle is involved in life span regulation; this mechanism may be conserved across phylogeny. ..
  3. Pujol C, Bratić Hench I, Sumakovic M, Hench J, Mourier A, Baumann L, et al. Succinate dehydrogenase upregulation destabilize complex I and limits the lifespan of gas-1 mutant. PLoS ONE. 2013;8:e59493 pubmed publisher