Gene Symbol: hsp-3
Description: Heat Shock Protein;Heat shock 70 kDa protein C
Alias: Heat Shock Protein;Heat shock 70 kDa protein C
Species: Caenorhabditis elegans
Shen X, Ellis R, Lee K, Liu C, Yang K, Solomon A, et al
. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell. 2001;107:893-903 pubmed
..We propose that UPR transcriptional activation by ire-1 as well as translational attenuation by pek-1 maintain ER homeostasis. The results demonstrate that the UPR and ER homeostasis are essential for metazoan development. ..
Kapulkin W, Kapulkin V, Hiester B, Link C. Compensatory regulation among ER chaperones in C. elegans. FEBS Lett. 2005;579:3063-8 pubmed
..We show that this compensatory regulation is specific for ER chaperones, not dependent on RNA interference, and required for maintaining viability in worms containing a deletion of the hsp-3 gene. ..
Urano F, Calfon M, Yoneda T, Yun C, Kiraly M, Clark S, et al
. A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. J Cell Biol. 2002;158:639-46 pubmed
Heschl M, Baillie D. The HSP70 multigene family of Caenorhabditis elegans. Comp Biochem Physiol B. 1990;96:633-7 pubmed
..5. The identification and characterization of C. elegans hsp70 multigene family is the basis for a genetic characterization of the regulation and function of a gene family during the development of a multicellular eukaryote...
Sasagawa Y, Yamanaka K, Ogura T. ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans. Genes Cells. 2007;12:1063-73 pubmed
..We propose that E3 ubiquitin ligases function in concert with a specific partner chaperone. ..
Couillault C, Fourquet P, Pophillat M, Ewbank J. A UPR-independent infection-specific role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis. Virulence. 2012;3:299-308 pubmed publisher
..The precise function of hsp-3 has yet to be determined, but these results uncover a hitherto unsuspected link between a BiP/GRP78 family protein and innate immune signaling. ..