Gene Symbol: hsp-1
Description: Heat shock 70 kDa protein A
Alias: Heat shock 70 kDa protein A
Species: Caenorhabditis elegans
Products:     hsp-1

Top Publications

  1. Hoppe T, Cassata G, Barral J, Springer W, Hutagalung A, Epstein H, et al. Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans. Cell. 2004;118:337-49 pubmed
    ..These results identify CHN-1 and UFD-2 as a functional E3/E4 complex and UNC-45 as its physiologically relevant substrate. ..
  2. Snutch T, Heschl M, Baillie D. The Caenorhabditis elegans hsp70 gene family: a molecular genetic characterization. Gene. 1988;64:241-55 pubmed
    ..Finally, utilizing strain-specific restriction fragment length differences, we have mapped the chromosomal position of hsp70A to the far right of chromosome IV. ..
  3. Singh V, Aballay A. Regulation of DAF-16-mediated Innate Immunity in Caenorhabditis elegans. J Biol Chem. 2009;284:35580-7 pubmed publisher
    ..These studies reveal a stress-inducible mechanism involved in the regulation of DAF-16 and indicate that uncontrolled DAF-16 activity and water homeostasis are a cause of the deleterious effects of excessive immune responses. ..
  4. Cui M, Fay D, Han M. lin-35/Rb cooperates with the SWI/SNF complex to control Caenorhabditis elegans larval development. Genetics. 2004;167:1177-85 pubmed
    ..Our results suggest that LIN-35/Rb and a certain class B synMuv proteins collaborate with the SWI/SNF protein complex to regulate the T cell division as well as other events essential for larval growth...
  5. Poteryaev D, Squirrell J, Campbell J, White J, Spang A. Involvement of the actin cytoskeleton and homotypic membrane fusion in ER dynamics in Caenorhabditis elegans. Mol Biol Cell. 2005;16:2139-53 pubmed
    ..Both proteins have been implicated in homotypic ER membrane fusion. We provide evidence that homotypic membrane fusion is required to form the sheet structure in the early embryo. ..
  6. Gazda L, Pokrzywa W, Hellerschmied D, L we T, Forn I, Mueller Planitz F, et al. The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Cell. 2013;152:183-95 pubmed publisher
    ..Together, these findings uncover a filament assembly factor that directly couples myosin folding with myofilament formation...
  7. Morley J, Morimoto R. Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell. 2004;15:657-64 pubmed
    ..The interaction of ILS with HSF-1 could represent an important molecular strategy to couple the regulation of longevity with an ancient genetic switch that governs the ability of cells to sense and respond to stress. ..
  8. Kimura K, Tanaka N, Nakamura N, Takano S, Ohkuma S. Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans. J Biol Chem. 2007;282:5910-8 pubmed
    ..These results suggest that the reduction of HSP-6 causes defects in mitochondrial function at the final stage of aging, leading to mortality. ..
  9. Fukuzono T, Pastuhov S, Fukushima O, Li C, Hattori A, Iemura S, et al. Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi. Genes Cells. 2016;21:311-24 pubmed publisher
    ..We show that UNC-23 determines LRK-1 localization to the Golgi apparatus in cooperation with HSP-1. These results describe a chaperone-dependent mechanism through which LRK-1 localization is regulated. ..

More Information


  1. Song H, Lee W, An K, Lee H, Cho J, Park Z, et al. C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response. J Mol Biol. 2009;390:604-17 pubmed publisher
    ..In addition, sti-1(jh125) mutants have a shortened life span. Our results confirm that CeSTI-1 is a cochaperone protein that may maintain homeostatic functions during episodes of stress and can regulate longevity in nematodes. ..
  2. Rahmani P, Rogalski T, Moerman D. The C. elegans UNC-23 protein, a member of the BCL-2-associated athanogene (BAG) family of chaperone regulators, interacts with HSP-1 to regulate cell attachment and maintain hypodermal integrity. Worm. 2015;4:e1023496 pubmed publisher
    ..The interaction of UNC-23 with HSP-1 defines a role for HSP-1 function in the maintenance of muscle attachment during development. ..
  3. Gaiser A, Brandt F, Richter K. The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90. J Mol Biol. 2009;391:621-34 pubmed publisher
    ..These results imply that, at least in C. elegans, essential functions of Hop exist which apparently do not depend on the simultaneous binding of Hsp90 and Hsp70 to Hop. ..
  4. Shi A, Sun L, Banerjee R, Tobin M, Zhang Y, Grant B. Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8. EMBO J. 2009;28:3290-302 pubmed publisher
    ..Our results indicate a mechanism, whereby retromer can regulate endosomal clathrin dynamics through RME-8 and Hsc70, promoting the sorting of recycling cargo into the retrograde pathway. ..
  5. Schäffer U, Schlosser A, Müller K, Schäfer A, Katava N, Baumeister R, et al. SnAvi--a new tandem tag for high-affinity protein-complex purification. Nucleic Acids Res. 2010;38:e91 pubmed publisher
    ..elegans for tandem affinity purification of protein complexes, western blotting and also for the in vivo sub-cellular localization of labelled proteins. ..
  6. Ferguson A, Springer M, Fisher A. skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans. Mol Cell Biol. 2010;30:2651-67 pubmed publisher
    ..These may be triggered by proteosome dysfunction, as we find that this event links the multiple inducers of aip-1. Together, our results show that cell stress triggers aip-1 expression by both skn-1-dependent and -independent pathways. ..
  7. Chen D, Jian Y, Liu X, Zhang Y, Liang J, Qi X, et al. Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003517 pubmed publisher
    ..These findings reveal a non-classical role of clathrin and AP2 and establish them as indispensable regulators in phagocytic receptor-mediated apoptotic cell clearance...