Gene Symbol: hsf-1
Description: Heat Shock Factor
Alias: Heat Shock Factor
Species: Caenorhabditis elegans

Top Publications

  1. Walker G, Thompson F, Brawley A, Scanlon T, Devaney E. Heat shock factor functions at the convergence of the stress response and developmental pathways in Caenorhabditis elegans. FASEB J. 2003;17:1960-2 pubmed
    b>Heat shock factor (HSF) is best characterized as the transcriptional regulator of heat shock protein genes, required by all cells to survive periods of stress...
  2. Singh V, Aballay A. Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity. Proc Natl Acad Sci U S A. 2006;103:13092-7 pubmed
    ..Considering that several coinducers of HSF-1 are currently in clinical trials, this work opens the possibility that activation of HSF-1 could be used to boost immunity to treat infectious diseases and immunodeficiencies. ..
  3. Singh V, Aballay A. Heat shock and genetic activation of HSF-1 enhance immunity to bacteria. Cell Cycle. 2006;5:2443-6 pubmed
    ..elegans homologue of Hsp90 which forms an inhibitory complex with HSF-1, appear to boost immunity by activating the HSF-1 pathway. The role of the HSF-1 pathway in innate immunity and immunosenescence is discussed...
  4. Morley J, Morimoto R. Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell. 2004;15:657-64 pubmed
    ..We therefore examined the role of heat shock factor (HSF-1), a master transcriptional regulator of stress-inducible gene expression and protein folding ..
  5. Wolff S, Ma H, Burch D, Maciel G, Hunter T, Dillin A. SMK-1, an essential regulator of DAF-16-mediated longevity. Cell. 2006;124:1039-53 pubmed
    ..SMK-1 therefore plays a role in longevity by modulating DAF-16 transcriptional specificity without affecting other processes regulated by IIS. ..
  6. Hsu A, Murphy C, Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science. 2003;300:1142-5 pubmed
    ..The small heat-shock proteins also delay the onset of polyglutamine-expansion protein aggregation, suggesting that these proteins couple the normal aging process to this type of age-related disease. ..
  7. Chiang W, Ching T, Lee H, Mousigian C, Hsu A. HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity. Cell. 2012;148:322-34 pubmed publisher
    ..Both the formation of DHIC and the phosphorylation of DDL-1 are controlled by IIS. Our findings point to DDL-1/2 as a link between IIS and the HSF-1 pathway. ..
  8. Cohen E, Bieschke J, Perciavalle R, Kelly J, Dillin A. Opposing activities protect against age-onset proteotoxicity. Science. 2006;313:1604-10 pubmed
    ..The downstream transcription factors, heat shock factor 1, and DAF-16 regulate opposing disaggregation and aggregation activities to promote cellular survival in ..
  9. Hajdu Cronin Y, Chen W, Sternberg P. The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans. Genetics. 2004;168:1937-49 pubmed
    ..hsf-1 encodes the C. elegans homolog of the human heat-shock factor HSF1, and cyl-1 encodes a cyclin most similar to cyclin L. We believe HSF-1 acts in heat-shock-inducible transcription and CYL-1 acts more generally in gene expression. ..

More Information


  1. Baird N, Douglas P, Simic M, Grant A, Moresco J, Wolff S, et al. HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span. Science. 2014;346:360-3 pubmed publisher
  2. Dinh J, Angeloni J, Pederson D, Wang X, Cao M, Dong Y. Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS ONE. 2014;9:e103290 pubmed publisher
    ..Considering the level of conservation between the innate immune pathways of C. elegans and humans, the results of this study suggest that WCESP may also play an immunity-promoting role in higher order organisms. ..
  3. Joo H, Park S, Kim K, Kim M, Kim H, Park D, et al. HSF-1 is involved in regulation of ascaroside pheromone biosynthesis by heat stress in Caenorhabditis elegans. Biochem J. 2016;473:789-96 pubmed publisher
    ..Hence heat-stress-enhanced ascaroside production appears to be mediated at least in part by HSF-1, which seems to be important in adaptation strategies for coping with heat stress in this nematode. ..
  4. Lee S, Murphy C, Kenyon C. Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 2009;10:379-91 pubmed publisher
    ..transcription factors that are also inhibited by insulin signaling: the FOXO family member DAF-16 and the heat shock factor HSF-1. This effect involved the downregulation of an aquaporin glycerol channel, aqp-1...
  5. Zhou J, Zheng Y, Zeng Y, Wang J, Pei Z, Pang J. Marine derived xyloketal derivatives exhibit anti-stress and anti-ageing effects through HSF pathway in Caenorhabditis elegans. Eur J Med Chem. 2018;148:63-72 pubmed publisher
    ..Collectively, these data indicate that xyloketals have potential implications for further evaluation in anti-ageing studies. ..
  6. Li J, Chauve L, Phelps G, Brielmann R, Morimoto R. E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response. Genes Dev. 2016;30:2062-2075 pubmed
    ..Together, E2F and HSF-1 directly regulate a gene network, including a specific subset of chaperones, to promote protein biogenesis and anabolic metabolism, which are essential in development. ..
  7. Furuhashi T, Sakamoto K. Heat shock factor 1 prevents the reduction in thrashing due to heat shock in Caenorhabditis elegans. Biochem Biophys Res Commun. 2015;462:190-4 pubmed publisher
    b>Heat shock factor 1 (HSF-1) is activated by heat stress and induces the expression of heat shock proteins. However, the role of HSF-1 in thermotolerance remains unclear...
  8. Enoki Y, Sakurai H. Diversity in DNA recognition by heat shock transcription factors (HSFs) from model organisms. FEBS Lett. 2011;585:1293-8 pubmed publisher
    ..Further analysis of alternatively spliced HSF isoforms showed the importance of the C-terminal region in HSF-HSE interaction. ..
  9. Zhang M, Poplawski M, Yen K, Cheng H, Bloss E, Zhu X, et al. Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. PLoS Biol. 2009;7:e1000245 pubmed publisher
    ..Other factors implicated in lifespan extension are also CBP-binding partners, suggesting that CBP constitutes a common factor in the modulation of lifespan and disease burden by DR and the insulin/IGF1 signaling pathway. ..
  10. Johnson J, Rajamanoharan D, McCue H, Rankin K, Barclay J. Small Heat Shock Proteins Are Novel Common Determinants of Alcohol and Nicotine Sensitivity in Caenorhabditis elegans. Genetics. 2016;202:1013-27 pubmed publisher
    ..48 protein that specified its function in comparison to related small HSPs. Our findings establish and characterize a novel genetic determinant underlying sensitivity to diverse addictive substances. ..
  11. Anyanful A, Easley K, Benian G, Kalman D. Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity. Cell Host Microbe. 2009;5:450-62 pubmed publisher
    ..Our findings suggest that the molecular pathways that control innate immunity and lifespan may be regulated or "conditioned" by exposure to pathogens to allow survival in noxious environments. ..
  12. Das R, Melo J, Thondamal M, Morton E, Cornwell A, Crick B, et al. The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans. PLoS Genet. 2017;13:e1007038 pubmed publisher
    ..HPK-1 therefore provides a promising intervention point for pharmacological agents targeting the protein homeostasis system as a means of preserving robust longevity. ..
  13. Barna J, Princz A, Kosztelnik M, Hargitai B, Takacs Vellai K, Vellai T. Heat shock factor-1 intertwines insulin/IGF-1, TGF-? and cGMP signaling to control development and aging. BMC Dev Biol. 2012;12:32 pubmed publisher
    ..b>Heat shock factor-1 (HSF-1) functions as a major player in this response as it activates the transcription of genes coding for ..
  14. Shen X, Valencia C, Gao W, Cotten S, Dong B, Huang B, et al. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Cell Calcium. 2008;43:444-56 pubmed
    ..elegans. ..
  15. Tatum M, Ooi F, Chikka M, Chauve L, Martinez Velazquez L, Steinbusch H, et al. Neuronal serotonin release triggers the heat shock response in C. elegans in the absence of temperature increase. Curr Biol. 2015;25:163-174 pubmed publisher
    ..The ability of neurosensory release of serotonin to control cellular stress responses and activate HSF1 has powerful implications for the treatment of protein conformation diseases. ..
  16. de Pomerai D, Smith B, Dawe A, North K, Smith T, Archer D, et al. Microwave radiation can alter protein conformation without bulk heating. FEBS Lett. 2003;543:93-7 pubmed
    ..We also show that heat-shock responses both to heat and microwaves are suppressed after RNA interference ablating heat-shock factor function. ..
  17. Mouchiroud L, Molin L, Kasturi P, Triba M, Dumas M, Wilson M, et al. Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans. Aging Cell. 2011;10:39-54 pubmed publisher
    ..These findings suggest that inhibition of this transporter homolog in mammals might also promote a DR response. ..
  18. Mendenhall A, Crane M, Leiser S, Sutphin G, Tedesco P, Kaeberlein M, et al. Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci. 2017;72:1033-1037 pubmed publisher
    ..We hypothesize that reduced variation in gene expression may ultimately cause reduced variation in life span. ..
  19. Kumsta C, Hansen M. Hormetic heat shock and HSF-1 overexpression improve C. elegans survival and proteostasis by inducing autophagy. Autophagy. 2017;13:1076-1077 pubmed publisher
    ..Collectively, we demonstrate a critical role for autophagy in C. elegans stress resistance and hormesis, and reveal a requirement for autophagy in HSF-1 regulated functions in the heat-shock response, proteostasis, and aging. ..
  20. Cornils A, Maurya A, Tereshko L, Kennedy J, Brear A, Prahlad V, et al. Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging. PLoS Genet. 2016;12:e1006325 pubmed publisher
    ..age-dependent suppression of cilia phenotypes in IFT mutants requires cell-autonomous functions of the HSF1 heat shock factor and the Hsp90 chaperone...
  21. Brunquell J, Bowers P, Westerheide S. Fluorodeoxyuridine enhances the heat shock response and decreases polyglutamine aggregation in an HSF-1-dependent manner in Caenorhabditis elegans. Mech Ageing Dev. 2014;141-142:1-4 pubmed publisher
    ..Therefore, FUdR treatment can modulate the HSR and proteostasis, and should be used with caution when used to inhibit reproduction. ..
  22. Schipanski A, Lange S, Segref A, Gutschmidt A, Lomas D, Miranda E, et al. A novel interaction between aging and ER overload in a protein conformational dementia. Genetics. 2013;193:865-76 pubmed publisher
    ..These data suggest that targets aimed at increasing UPR capacity in neurons are valuable tools for therapeutic intervention. ..
  23. Morton E, Lamitina T. Caenorhabditis elegans HSF-1 is an essential nuclear protein that forms stress granule-like structures following heat shock. Aging Cell. 2013;12:112-20 pubmed publisher
    ..Our findings suggest that development, stress, and aging pathways may regulate HSF-1 function in distinct ways, and that HSF-1 nuclear stress granule formation is an evolutionarily conserved aspect of HSF-1 regulation in vivo. ..
  24. Garigan D, Hsu A, Fraser A, Kamath R, Ahringer J, Kenyon C. Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics. 2002;161:1101-12 pubmed
    ..Finally, we have identified a cause of death of C. elegans: namely, proliferating bacteria. This suggests that increased susceptibility to bacterial infections contributes to mortality in these animals, just as it does in humans. ..
  25. Labbadia J, Morimoto R. Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction. Mol Cell. 2015;59:639-50 pubmed publisher
    ..These findings suggest that competing requirements of the germline and soma dictate organismal stress resistance as animals begin reproduction. ..
  26. Wang J, Farr G, Hall D, Li F, Furtak K, Dreier L, et al. An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans. PLoS Genet. 2009;5:e1000350 pubmed publisher
    ..At the EM level, mutant animals exhibited a reduced number of synaptic vesicles. Neurotoxicity in this system thus appears to be mediated by misfolded SOD1 and is exerted on synaptic vesicle biogenesis and/or trafficking. ..