hrdl-1

Summary

Gene Symbol: hrdl-1
Description: E3 ubiquitin-protein ligase hrd-like protein 1
Alias: E3 ubiquitin-protein ligase hrd-like protein 1
Species: Caenorhabditis elegans

Top Publications

  1. Quevedo C, Kaplan D, Derry W. AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Curr Biol. 2007;17:286-92 pubmed
    ..Finally, we show that AKT-1 regulates apoptosis but not cell-cycle progression downstream of the HUS-1/MRT-2 branch of the DNA damage checkpoint. ..
  2. Sasagawa Y, Yamanaka K, Ogura T. ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans. Genes Cells. 2007;12:1063-73 pubmed
    ..We propose that E3 ubiquitin ligases function in concert with a specific partner chaperone. ..
  3. Hamamichi S, Rivas R, Knight A, Cao S, Caldwell K, Caldwell G. Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Proc Natl Acad Sci U S A. 2008;105:728-33 pubmed publisher
    ..These data represent putative genetic susceptibility loci and potential therapeutic targets for PD, a movement disorder affecting approximately 2% of the population over 65 years of age. ..