Gene Symbol: hpk-1
Description: Homeodomain interacting Protein Kinase;Homeodomain-interacting protein kinase 1
Alias: Homeodomain interacting Protein Kinase;Homeodomain-interacting protein kinase 1
Species: Caenorhabditis elegans
Raich W, Moorman C, Lacefield C, Lehrer J, Bartsch D, Plasterk R, et al
. Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A. Genetics. 2003;163:571-80 pubmed
..Our results suggest that increased gene dosage of human DYRK1A in trisomy 21 may disrupt the function of fully differentiated neurons and that this disruption is reversible. ..
Berber S, Wood M, Llamosas E, Thaivalappil P, Lee K, Liao B, et al
. Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans. Sci Rep. 2016;6:19582 pubmed publisher
..Lastly, we show that HPK-1 functions in the same pathway as DAF-16 to regulate longevity and reveal a new role for HPK-1 in development. ..
Berber S, Llamosas E, Thaivalappil P, Boag P, Crossley M, Nicholas H. Homeodomain interacting protein kinase (HPK-1) is required in the soma for robust germline proliferation in C. elegans. Dev Dyn. 2013;242:1250-61 pubmed publisher
..Our observations are consistent with a conserved role for HIPKs in the control of cellular proliferation and identify a new context for such control in germ cell proliferation...
Das R, Melo J, Thondamal M, Morton E, Cornwell A, Crick B, et al
. The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans. PLoS Genet. 2017;13:e1007038 pubmed publisher
..HPK-1 therefore provides a promising intervention point for pharmacological agents targeting the protein homeostasis system as a means of preserving robust longevity. ..