hpd-1

Summary

Gene Symbol: hpd-1
Description: 4-hydroxyphenylpyruvate dioxygenase
Alias: 4-hydroxyphenylpyruvate dioxygenase
Species: Caenorhabditis elegans

Top Publications

  1. Lee S, Kennedy S, Tolonen A, Ruvkun G. DAF-16 target genes that control C. elegans life-span and metabolism. Science. 2003;300:644-7 pubmed
    ..elegans, and RNA interference inactivation of the candidates showed that many of these genes mediate distinct aspects of daf-16 function, including longevity, metabolism, and development. ..
  2. Yuan Y, Kadiyala C, Ching T, Hakimi P, Saha S, Xu H, et al. Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans. J Biol Chem. 2012;287:31414-26 pubmed publisher
    ..We conclude that an increase, not a decrease in fuel consumption, via an accelerated oxidation of fuels in the TCA cycle is involved in life span regulation; this mechanism may be conserved across phylogeny. ..