hmr-1

Summary

Gene Symbol: hmr-1
Description: Cadherin-related hmr-1
Alias: Cadherin-related hmr-1
Species: Caenorhabditis elegans
Products:     hmr-1

Top Publications

  1. Costa M, Raich W, Agbunag C, Leung B, Hardin J, Priess J. A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo. J Cell Biol. 1998;141:297-308 pubmed
    ..This putative catenin-cadherin system is not essential for general cell adhesion in the C. elegans embryo, but rather mediates specific aspects of morphogenetic cell shape change and cytoskeletal organization. ..
  2. Grana T, Cox E, Lynch A, Hardin J. SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation during Caenorhabditis elegans gastrulation. Dev Biol. 2010;344:731-44 pubmed publisher
  3. Kennedy S, Wang D, Ruvkun G. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature. 2004;427:645-9 pubmed
    ..Thus, ERI-1 is a negative regulator that may normally function to limit the duration, cell-type specificity or endogenous functions of RNA interference. ..
  4. Padmanabhan A, Ong H, Zaidel Bar R. Non-junctional E-Cadherin Clusters Regulate the Actomyosin Cortex in the C. elegans Zygote. Curr Biol. 2017;27:103-112 pubmed publisher
  5. Pettitt J, Cox E, Broadbent I, Flett A, Hardin J. The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis. J Cell Biol. 2003;162:15-22 pubmed
    ..These results suggest that JAC-1 acts as a positive modulator of cadherin function in C. elegans. ..
  6. Gillard G, Shafaq Zadah M, Nicolle O, Damaj R, Pécréaux J, Michaux G. Control of E-cadherin apical localisation and morphogenesis by a SOAP-1/AP-1/clathrin pathway in C. elegans epidermal cells. Development. 2015;142:1684-94 pubmed publisher
    ..We therefore propose that a molecular pathway, containing SOAP-1, AP-1 and clathrin, controls the apical delivery of E-cad and morphogenesis. ..
  7. Korswagen H, Coudreuse D, Betist M, van de Water S, Zivkovic D, Clevers H. The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes Dev. 2002;16:1291-302 pubmed
    ..We conclude that a highly divergent destruction complex consisting of PRY-1, SGG-1, and APR-1 regulates BAR-1/beta-catenin signaling in C. elegans. ..
  8. Wang D, Ruvkun G. Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway. Cold Spring Harb Symp Quant Biol. 2004;69:429-31 pubmed
  9. Callaci S, Morrison K, Shao X, Schuh A, Wang Y, Yates J, et al. Phosphoregulation of the C. elegans cadherin-catenin complex. Biochem J. 2015;472:339-52 pubmed publisher
    ..Collectively, our findings support a model in which distinct phosphorylation events contribute to rapid CCC assembly and disassembly, both of which are essential for morphogenetic rearrangements during development. ..

More Information

Publications18

  1. Oosterveen T, Coudreuse D, Yang P, Fraser E, Bergsma J, Dale T, et al. Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans. Dev Biol. 2007;308:438-48 pubmed
    ..We conclude that Axin function in C. elegans is divided over two different Axin orthologs that have specific functions in negatively regulating canonical Wnt signaling. ..
  2. Tsur A, Bening Abu Shach U, Broday L. ULP-2 SUMO Protease Regulates E-Cadherin Recruitment to Adherens Junctions. Dev Cell. 2015;35:63-77 pubmed publisher
    ..Our study provides a mechanistic link between the dynamic nature of the SUMO machinery and AJ plasticity and highlight sumoylation as a molecular switch that modulates the binding of E-cadherin to the actin cytoskeleton. ..
  3. Chihara D, Nance J. An E-cadherin-mediated hitchhiking mechanism for C. elegans germ cell internalization during gastrulation. Development. 2012;139:2547-56 pubmed publisher
    ..Our findings reveal that quiescent PGCs employ a post-transcriptionally regulated hitchhiking mechanism to internalize during gastrulation, and demonstrate a morphogenetic role for the conserved association of PGCs with the endoderm...
  4. Korswagen H, Herman M, Clevers H. Distinct beta-catenins mediate adhesion and signalling functions in C. elegans. Nature. 2000;406:527-32 pubmed
    ..elegans, HMR-1. We conclude that a canonical Wnt pathway exists in C. elegans. Furthermore, our analysis shows that the functions of C. elegans beta-catenins in adhesion and in signalling are performed by separate proteins. ..
  5. Klompstra D, Anderson D, Yeh J, Zilberman Y, Nance J. An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity. Nat Cell Biol. 2015;17:726-35 pubmed publisher
    ..Our findings identify an E-cadherin-mediated pathway that translates cell contacts into cortical polarity by directly recruiting a symmetry-breaking factor to the adjacent cortex. ..
  6. Sawyer J, Glass S, Li T, Shemer G, White N, Starostina N, et al. Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans. Genetics. 2011;188:549-64 pubmed publisher
    ..Our results implicate new genes in C. elegans gastrulation, and they show that an RNAi-based enhancer screen in C. elegans can be used as an efficient means to identify important but redundant or partially redundant developmental genes. ..
  7. Mizumoto K, Sawa H. Cortical beta-catenin and APC regulate asymmetric nuclear beta-catenin localization during asymmetric cell division in C. elegans. Dev Cell. 2007;12:287-99 pubmed
    ..Because beta-catenin and APC are localized to the cortex in many cell types in different species, our results suggest that these cortical proteins may regulate asymmetric divisions or Wnt signaling in other organisms as well. ..
  8. Broadbent I, Pettitt J. The C. elegans hmr-1 gene can encode a neuronal classic cadherin involved in the regulation of axon fasciculation. Curr Biol. 2002;12:59-63 pubmed
    ..These results indicate that Drosophila and C. elegans share a conserved, cadherin-dependent mechanism involved in regulating axonal patterning and fasciculation. ..
  9. Kang H, Bang I, Jin K, Lee B, Lee J, Shao X, et al. Structural and functional characterization of Caenorhabditis elegans α-catenin reveals constitutive binding to β-catenin and F-actin. J Biol Chem. 2017;292:7077-7086 pubmed publisher