Gene Symbol: hmp-2
Description: Beta-catenin-like protein hmp-2;HuMPback (dorsal lumps)
Alias: Beta-catenin-like protein hmp-2;HuMPback (dorsal lumps)
Species: Caenorhabditis elegans

Top Publications

  1. Natarajan L, Witwer N, Eisenmann D. The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo. Genetics. 2001;159:159-72 pubmed
    ..elegans, these proteins still retain sufficient similarity to display functional redundancy in vivo. ..
  2. Pettitt J, Cox E, Broadbent I, Flett A, Hardin J. The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis. J Cell Biol. 2003;162:15-22 pubmed
    ..These results suggest that JAC-1 acts as a positive modulator of cadherin function in C. elegans. ..
  3. Costa M, Raich W, Agbunag C, Leung B, Hardin J, Priess J. A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo. J Cell Biol. 1998;141:297-308 pubmed
    ..This putative catenin-cadherin system is not essential for general cell adhesion in the C. elegans embryo, but rather mediates specific aspects of morphogenetic cell shape change and cytoskeletal organization. ..
  4. Callaci S, Morrison K, Shao X, Schuh A, Wang Y, Yates J, et al. Phosphoregulation of the C. elegans cadherin-catenin complex. Biochem J. 2015;472:339-52 pubmed publisher
    ..Collectively, our findings support a model in which distinct phosphorylation events contribute to rapid CCC assembly and disassembly, both of which are essential for morphogenetic rearrangements during development. ..
  5. Dudley N, Labbé J, Goldstein B. Using RNA interference to identify genes required for RNA interference. Proc Natl Acad Sci U S A. 2002;99:4191-6 pubmed
    ..The finding that genes predicted to encode proteins that associate with chromatin are involved in RNAi in C. elegans raises the possibility that chromatin may play a role in RNAi in animals, as it does in plants. ..
  6. Putzke A, Hikita S, Clegg D, Rothman J. Essential kinase-independent role of a Fer-like non-receptor tyrosine kinase in Caenorhabditis elegans morphogenesis. Development. 2005;132:3185-95 pubmed
    ..Thus, FRK-1 performs a kinase-independent function in differentiation and morphogenesis of the C. elegans epidermis during embryogenesis. ..
  7. Sumiyoshi E, Takahashi S, Obata H, Sugimoto A, Kohara Y. The ?-catenin HMP-2 functions downstream of Src in parallel with the Wnt pathway in early embryogenesis of C. elegans. Dev Biol. 2011;355:302-12 pubmed publisher
    ..Taken together, we propose that HMP-2 functions downstream of the Src signaling pathway and contribute to endoderm induction and ABar spindle orientation, in parallel with the Wnt signaling pathway. ..
  8. Shao X, Kang H, Loveless T, Lee G, Seok C, Weis W, et al. Cell-cell adhesion in metazoans relies on evolutionarily conserved features of the ?-catenin·?-catenin-binding interface. J Biol Chem. 2017;292:16477-16490 pubmed publisher
    ..elegans Our data provide novel insights into how cadherin-dependent cell-cell adhesion is modulated in metazoans by conserved elements as well as features unique to specific organisms. ..
  9. Zaidel Bar R, Joyce M, Lynch A, Witte K, Audhya A, Hardin J. The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis. J Cell Biol. 2010;191:761-9 pubmed publisher
    ..These studies establish a new role for this conserved protein family in modulating cell-cell adhesion. ..

More Information


  1. Cabello J, Neukomm L, Günesdogan U, Burkart K, Charette S, Lochnit G, et al. The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. PLoS Biol. 2010;8:e1000297 pubmed publisher
    ..Taken together, our results indicate that in multiple developmental processes, CED-10/Rac can link polar signals mediated by the Wnt pathway to rearrangements of the cytoskeleton. ..
  2. Tsur A, Bening Abu Shach U, Broday L. ULP-2 SUMO Protease Regulates E-Cadherin Recruitment to Adherens Junctions. Dev Cell. 2015;35:63-77 pubmed publisher
    ..Our study provides a mechanistic link between the dynamic nature of the SUMO machinery and AJ plasticity and highlight sumoylation as a molecular switch that modulates the binding of E-cadherin to the actin cytoskeleton. ..
  3. Grana T, Cox E, Lynch A, Hardin J. SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation during Caenorhabditis elegans gastrulation. Dev Biol. 2010;344:731-44 pubmed publisher
  4. Stetak A, Hörndli F, Maricq A, van den Heuvel S, Hajnal A. Neuron-specific regulation of associative learning and memory by MAGI-1 in C. elegans. PLoS ONE. 2009;4:e6019 pubmed publisher
    ..elegans are likely carried out by distinct subsets of interneurons. The synaptic scaffolding protein MAGI-1 plays a critical role in these processes in part by regulating the clustering of iGluRs at synapses. ..
  5. Oosterveen T, Coudreuse D, Yang P, Fraser E, Bergsma J, Dale T, et al. Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans. Dev Biol. 2007;308:438-48 pubmed
    ..We conclude that Axin function in C. elegans is divided over two different Axin orthologs that have specific functions in negatively regulating canonical Wnt signaling. ..
  6. Korswagen H, Herman M, Clevers H. Distinct beta-catenins mediate adhesion and signalling functions in C. elegans. Nature. 2000;406:527-32 pubmed
    ..elegans, HMR-1. We conclude that a canonical Wnt pathway exists in C. elegans. Furthermore, our analysis shows that the functions of C. elegans beta-catenins in adhesion and in signalling are performed by separate proteins. ..
  7. Putzke A, Rothman J. Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase. Proc Natl Acad Sci U S A. 2010;107:16154-9 pubmed publisher
    ..These findings highlight a role for a Fer-type kinase in setting the proper levels of Wnt signaling and demonstrate the importance of this modulation in ensuring appropriate cell division. ..
  8. Kang H, Bang I, Jin K, Lee B, Lee J, Shao X, et al. Structural and functional characterization of Caenorhabditis elegans α-catenin reveals constitutive binding to β-catenin and F-actin. J Biol Chem. 2017;292:7077-7086 pubmed publisher
  9. Korswagen H, Coudreuse D, Betist M, van de Water S, Zivkovic D, Clevers H. The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes Dev. 2002;16:1291-302 pubmed
    ..We conclude that a highly divergent destruction complex consisting of PRY-1, SGG-1, and APR-1 regulates BAR-1/beta-catenin signaling in C. elegans. ..