hmp-1

Summary

Gene Symbol: hmp-1
Description: Alpha-catenin-like protein hmp-1;HuMPback (dorsal lumps)
Alias: Alpha-catenin-like protein hmp-1;HuMPback (dorsal lumps)
Species: Caenorhabditis elegans

Top Publications

  1. Costa M, Raich W, Agbunag C, Leung B, Hardin J, Priess J. A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo. J Cell Biol. 1998;141:297-308 pubmed
    ..This putative catenin-cadherin system is not essential for general cell adhesion in the C. elegans embryo, but rather mediates specific aspects of morphogenetic cell shape change and cytoskeletal organization. ..
  2. Natarajan L, Witwer N, Eisenmann D. The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo. Genetics. 2001;159:159-72 pubmed
    ..elegans, these proteins still retain sufficient similarity to display functional redundancy in vivo. ..
  3. Pettitt J, Cox E, Broadbent I, Flett A, Hardin J. The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis. J Cell Biol. 2003;162:15-22 pubmed
    ..These results suggest that JAC-1 acts as a positive modulator of cadherin function in C. elegans. ..
  4. Segbert C, Johnson K, Theres C, Van Fürden D, Bossinger O. Molecular and functional analysis of apical junction formation in the gut epithelium of Caenorhabditis elegans. Dev Biol. 2004;266:17-26 pubmed
    ..elegans intestine. ..
  5. Grana T, Cox E, Lynch A, Hardin J. SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation during Caenorhabditis elegans gastrulation. Dev Biol. 2010;344:731-44 pubmed publisher
  6. Kwiatkowski A, Maiden S, Pokutta S, Choi H, Benjamin J, Lynch A, et al. In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2010;107:14591-6 pubmed publisher
    ..Our study defines evolutionarily conserved properties of alpha-catenin and suggests that multiple mechanisms regulate alpha-catenin binding to F-actin. ..
  7. Cox Paulson E, Walck Shannon E, Lynch A, Yamashiro S, Zaidel Bar R, Eno C, et al. Tropomodulin protects ?-catenin-dependent junctional-actin networks under stress during epithelial morphogenesis. Curr Biol. 2012;22:1500-5 pubmed publisher
    ..Our data suggest that Tmods protect actin filaments recruited by ?-catenin from minus-end subunit loss, enabling them to withstand the stresses of morphogenesis. ..
  8. Maiden S, Harrison N, Keegan J, Cain B, Lynch A, Pettitt J, et al. Specific conserved C-terminal amino acids of Caenorhabditis elegans HMP-1/?-catenin modulate F-actin binding independently of vinculin. J Biol Chem. 2013;288:5694-706 pubmed publisher
    ..Our studies are the first to identify key conserved amino acids in the C terminus of ?-catenin that modulate F-actin binding in living embryos of a simple metazoan...
  9. Callaci S, Morrison K, Shao X, Schuh A, Wang Y, Yates J, et al. Phosphoregulation of the C. elegans cadherin-catenin complex. Biochem J. 2015;472:339-52 pubmed publisher
    ..Collectively, our findings support a model in which distinct phosphorylation events contribute to rapid CCC assembly and disassembly, both of which are essential for morphogenetic rearrangements during development. ..

More Information

Publications12

  1. Kang H, Bang I, Jin K, Lee B, Lee J, Shao X, et al. Structural and functional characterization of Caenorhabditis elegans α-catenin reveals constitutive binding to β-catenin and F-actin. J Biol Chem. 2017;292:7077-7086 pubmed publisher
  2. Shao X, Kang H, Loveless T, Lee G, Seok C, Weis W, et al. Cell-cell adhesion in metazoans relies on evolutionarily conserved features of the ?-catenin·?-catenin-binding interface. J Biol Chem. 2017;292:16477-16490 pubmed publisher
    ..elegans Our data provide novel insights into how cadherin-dependent cell-cell adhesion is modulated in metazoans by conserved elements as well as features unique to specific organisms. ..
  3. Lockwood C, Zaidel Bar R, Hardin J. The C. elegans zonula occludens ortholog cooperates with the cadherin complex to recruit actin during morphogenesis. Curr Biol. 2008;18:1333-7 pubmed publisher
    ..These results show that ZOO-1 cooperates with the cadherin-catenin complex to dynamically regulate strong junctional anchorage to the actin cytoskeleton during morphogenesis. ..