Gene Symbol: hlh-8
Description: Twist-related protein
Alias: Twist-related protein
Species: Caenorhabditis elegans
Harfe B, Vaz Gomes A, Kenyon C, Liu J, Krause M, Fire A. Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning. Genes Dev. 1998;12:2623-35 pubmed
..These results suggest the possibility that a conserved pathway may be used for diverse functions in mesodermal specification. ..
Kostas S, Fire A. The T-box factor MLS-1 acts as a molecular switch during specification of nonstriated muscle in C. elegans. Genes Dev. 2002;16:257-69 pubmed
..mls-1 activity also appears to be regulated by posttranscriptional processes, as expression occurs in both uterine and vulval muscle precursors. ..
Firulli B, Krawchuk D, Centonze V, Vargesson N, Virshup D, Conway S, et al
. Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet. 2005;37:373-81 pubmed publisher
Wang P, Zhao J, Corsi A. Identification of novel target genes of CeTwist and CeE/DA. Dev Biol. 2006;293:486-98 pubmed
..Human homologues of two of these genes might be involved in craniofacial diseases, which further validates C. elegans as a good model organism for providing insights into these disorders. ..
Philogene M, Small S, Wang P, Corsi A. Distinct Caenorhabditis elegans HLH-8/twist-containing dimers function in the mesoderm. Dev Dyn. 2012;241:481-92 pubmed publisher
..The use of distinct Twist dimers is evolutionarily conserved, and C. elegans provides a paradigm for future dissection of differential promoter regulation by these dimers at a single cell resolution. ..
Meyers S, Corsi A. C. elegans twist gene expression in differentiated cell types is controlled by autoregulation through intron elements. Dev Biol. 2010;346:224-36 pubmed publisher
..The findings could also be relevant to understanding human Twist gene regulation, which is currently not well understood. ..
Tian C, Shi H, Colledge C, Stern M, Waterston R, Liu J. The C. elegans SoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm. Development. 2011;138:1033-43 pubmed publisher
..elegans M lineage suggests a possible more general link between Hox-PBC factors and SoxC proteins in regulating cell proliferation. ..