hel-1

Summary

Gene Symbol: hel-1
Description: Spliceosome RNA helicase DDX39B homolog
Alias: Spliceosome RNA helicase DDX39B homolog
Species: Caenorhabditis elegans

Top Publications

  1. MacMorris M, Brocker C, Blumenthal T. UAP56 levels affect viability and mRNA export in Caenorhabditis elegans. RNA. 2003;9:847-57 pubmed
    ..elegans, but that REF/Aly may not. It also appears that some RNA processing factors are required for viability (e.g., U2AF, PUF60, SRp54, SAP49, PRP8, U1-70K), whereas others are not (e.g., U2A', CstF50). ..
  2. Longman D, Johnstone I, Caceres J. The Ref/Aly proteins are dispensable for mRNA export and development in Caenorhabditis elegans. RNA. 2003;9:881-91 pubmed
    ..Furthermore, no defects in mRNA export were observed upon simultaneous depletion of all three REF proteins. These results suggest the existence of multiple adaptor proteins that mediate mRNA export in C. elegans. ..
  3. Seo M, Seo K, Hwang W, Koo H, Hahm J, Yang J, et al. RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2015;112:E4246-55 pubmed publisher
    ..Because HEL-1 and IIS are evolutionarily well conserved, a similar mechanism for longevity regulation via an RNA helicase-dependent regulation of FOXO signaling may operate in mammals, including humans. ..