Gene Symbol: hda-1
Description: Histone deacetylase 1
Alias: Histone deacetylase 1
Species: Caenorhabditis elegans

Top Publications

  1. Lu X, Horvitz H. lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48. Cell. 1998;95:981-91 pubmed
    ..We propose that LIN-35 and LIN-53 antagonize the Ras signaling pathway in C. elegans by repressing transcription in the vulval precursor cells of genes required for the expression of vulval cell fates. ..
  2. Calvo D, Victor M, Gay F, Sui G, Luke M, Dufourcq P, et al. A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis. EMBO J. 2001;20:7197-208 pubmed
    ..Furthermore, they identify a strategy by which concerted actions of histone deacetylases and other co-repressors ensure maximal repression of inappropriate cell type-specific gene transcription. ..
  3. Solari F, Ahringer J. NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans. Curr Biol. 2000;10:223-6 pubmed
    ..These results emphasise the importance of chromatin regulation in developmental decisions. Furthermore, inhibition of Ras signaling suggests a possible link between NURD function and cancer. ..
  4. Dufourcq P, Victor M, Gay F, Calvo D, Hodgkin J, Shi Y. Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis. Mol Cell Biol. 2002;22:3024-34 pubmed
    ..We previously demonstrated that inhibition of maternal and zygotic expression of histone deacetylase 1 (HDA-1) causes embryonic lethality in Caenorhabditis elegans...
  5. Unhavaithaya Y, Shin T, Miliaras N, Lee J, Oyama T, Mello C. MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans. Cell. 2002;111:991-1002 pubmed
  6. Zinovyeva A, Graham S, Cloud V, Forrester W. The C. elegans histone deacetylase HDA-1 is required for cell migration and axon pathfinding. Dev Biol. 2006;289:229-42 pubmed
    ..Together, our studies define a new role for HDA-1 in nervous system development, and provide the first evidence for HDAC function in regulating neuronal axon guidance. ..
  7. Poulin G, Dong Y, Fraser A, Hopper N, Ahringer J. Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans. EMBO J. 2005;24:2613-23 pubmed
    ..As most of the genes identified in this screen are conserved in humans, we suggest that similar interactions may be relevant in mammals for control of Ras and Notch signalling, crosstalk between these pathways, and cell proliferation...
  8. Whetstine J, Ceron J, Ladd B, Dufourcq P, Reinke V, Shi Y. Regulation of tissue-specific and extracellular matrix-related genes by a class I histone deacetylase. Mol Cell. 2005;18:483-90 pubmed
    ..Because human HDACs are targets for cancer therapy, these findings have significant implications in cancer treatment. ..
  9. Fay D, Qiu X, Large E, Smith C, Mango S, Johanson B. The coordinate regulation of pharyngeal development in C. elegans by lin-35/Rb, pha-1, and ubc-18. Dev Biol. 2004;271:11-25 pubmed

More Information


  1. Ranawade A, Cumbo P, Gupta B. Caenorhabditis elegans histone deacetylase hda-1 is required for morphogenesis of the vulva and LIN-12/Notch-mediated specification of uterine cell fates. G3 (Bethesda). 2013;3:1363-74 pubmed publisher
    ..Given that hda-1 homologs are conserved across the phyla, our findings are likely to provide a better understanding of HDAC1 function in development and disease. ..
  2. Shi Y, Mello C. A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans. Genes Dev. 1998;12:943-55 pubmed
    ..Our findings suggest a model in which CBP-1 may activate transcription and differentiation in C. elegans by directly or indirectly antagonizing a repressive effect of histone deacetylase. ..
  3. Schaner C, Deshpande G, Schedl P, Kelly W. A conserved chromatin architecture marks and maintains the restricted germ cell lineage in worms and flies. Dev Cell. 2003;5:747-57 pubmed
    ..These results indicate that genome-wide repression via a nanos-regulated, germ cell-specific chromatin organization is a conserved feature of germline maintenance during embryogenesis. ..
  4. Grote P, Conradt B. The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans. Dev Cell. 2006;11:561-73 pubmed
    ..Similar interactions may function in sex determination and developmental regulation in other species. ..
  5. Choy S, Wong Y, Ho S, Chow K. C. elegans SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development. Biochem Biophys Res Commun. 2007;358:802-7 pubmed
    ..Conserved physical interactions between these components were also observed, implicating the recruitment of HDAC complex by MAB-21/SIN-3 may occur to determine ray identity in males. ..
  6. Hattori A, Mizuno T, Akamatsu M, Hisamoto N, Matsumoto K. The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex. PLoS Genet. 2013;9:e1003315 pubmed publisher
    ..This study describes the direct link from JNK signaling, Fos phosphorylation, and regulation of kreg gene transcription, which modulates the stress response in C. elegans...
  7. Pothof J, van Haaften G, Thijssen K, Kamath R, Fraser A, Ahringer J, et al. Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes Dev. 2003;17:443-8 pubmed
    ..Because known mutator genes are causally involved in many hereditary and sporadic human cancers, it is likely that some of these new mutators are equally relevant in cancer etiology. ..
  8. Matus D, Lohmer L, Kelley L, Schindler A, Kohrman A, Barkoulas M, et al. Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression. Dev Cell. 2015;35:162-74 pubmed publisher
    ..Together, these results suggest that invasive cell fate requires G1 arrest and that strategies targeting both G1-arrested and actively cycling cells may be needed to halt metastatic cancer. ..
  9. Fay D, Large E, Han M, Darland M. lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegans. Development. 2003;130:3319-30 pubmed
    ..lin-35 and ubc-18 may act in concert to regulate the levels of one or more critical targets during C. elegans development...
  10. Lee J, Lee J. Hypoxia-inducible Factor-1 (HIF-1)-independent hypoxia response of the small heat shock protein hsp-16.1 gene regulated by chromatin-remodeling factors in the nematode Caenorhabditis elegans. J Biol Chem. 2013;288:1582-9 pubmed publisher
    ..In addition, we found that calcineurin acts independently of hif-1 to modulate the cellular response to hypoxia and that calcium ions are necessary for the induction of hsp-16.1 under hypoxic conditions...