Gene Symbol: hcp-3
Description: Histone H3-like centromeric protein hcp-3
Alias: Histone H3-like centromeric protein hcp-3
Species: Caenorhabditis elegans
Severson A, Hamill D, Carter J, Schumacher J, Bowerman B. The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis. Curr Biol. 2000;10:1162-71 pubmed
..AIR-2 has two functions during mitosis: one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4. AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1. ..
Buchwitz B, Ahmad K, Moore L, Roth M, Henikoff S. A histone-H3-like protein in C. elegans. Nature. 1999;401:547-8 pubmed
Kaitna S, Pasierbek P, Jantsch M, Loidl J, Glotzer M. The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis. Curr Biol. 2002;12:798-812 pubmed
..Condensin mediates chromosome condensation during prophase, and condensin-independent pathways contribute to chromosome condensation during metaphase. ..
Lee B, Lin Z, Yuen K. RbAp46/48(LIN-53) Is Required for Holocentromere Assembly in Caenorhabditis elegans. Cell Rep. 2016;14:1819-28 pubmed publisher
..Nonetheless, depletion of RbAp46/48(LIN-53) leads to anaphase bridges and chromosome missegregation. This study unravels the holocentromere assembly hierarchy and its conservation with monocentromeres. ..
Oegema K, Desai A, Rybina S, Kirkham M, Hyman A. Functional analysis of kinetochore assembly in Caenorhabditis elegans. J Cell Biol. 2001;153:1209-26 pubmed
..Furthermore, kinetochore assembly and the recruitment of CeINCENP to chromosomes are independent. These results suggest distinct roles for the kinetochore and the chromosomal passengers in mitotic chromosome segregation. ..
Cheeseman I, Niessen S, Anderson S, Hyndman F, Yates J, Oegema K, et al
. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 2004;18:2255-68 pubmed
..Thus, this protein network is a conserved constituent of the outer kinetochore, and the functions defined by our analysis in C. elegans are likely to be widely relevant. ..
Monen J, Hattersley N, Muroyama A, Stevens D, Oegema K, Desai A. Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans. PLoS ONE. 2015;10:e0125382 pubmed publisher
Ferreira J, Stear J, Saumweber H. Nucleoporins NPP-10, NPP-13 and NPP-20 are required for HCP-4 nuclear import to establish correct centromere assembly. J Cell Sci. 2017;130:963-974 pubmed publisher
..In prometaphase and later mitotic stages after breakdown of the nuclear envelope, HCP-4 is not incorporated into centromeres. These results indicate that correct timing of the availability of HCP-4 by nuclear import is essential. ..
Stear J, Roth M. The Caenorhabditis elegans kinetochore reorganizes at prometaphase and in response to checkpoint stimuli. Mol Biol Cell. 2004;15:5187-96 pubmed
..These phenotypes suggest that these proteins, and by extension their reorganization during mitosis, are important for mediating the checkpoint response as well as directing the assembly of the metaphase plate. ..