Gene Symbol: hcp-2
Description: HoloCentric chromosome binding Protein
Alias: HoloCentric chromosome binding Protein
Species: Caenorhabditis elegans
Cheeseman I, MacLeod I, Yates J, Oegema K, Desai A. The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation. Curr Biol. 2005;15:771-7 pubmed
..Our results establish that the key role of HCP-1/2 is to target CLASP(CLS-2) to kinetochores, and they support the recently proposed model that CLASP functions to promote the polymerization of kinetochore bound microtubules . ..
Gassmann R, Essex A, Hu J, Maddox P, Motegi F, Sugimoto A, et al
. A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 2008;22:2385-99 pubmed publisher
Moore L, Morrison M, Roth M. HCP-1, a protein involved in chromosome segregation, is localized to the centromere of mitotic chromosomes in Caenorhabditis elegans. J Cell Biol. 1999;147:471-80 pubmed
..These results suggest that HCP-1 is a centromere-associated protein that is involved in the fidelity of chromosome segregation. ..
Aoki H, Sato S, Takanami T, Ishihara T, Katsura I, Takahashi H, et al
. Characterization of Ce-atl-1, an ATM-like gene from Caenorhabditis elegans. Mol Gen Genet. 2000;264:119-26 pubmed
..In summary, Ce-atl-1 appears to be important for early embryogenesis, and loss of its function results in a defect in chromosome segregation, similar to what has been observed for AT-related proteins. ..
Tarailo M, Tarailo S, Rose A. Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components. Genetics. 2007;177:2525-30 pubmed
Dumont J, Oegema K, Desai A. A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis. Nat Cell Biol. 2010;12:894-901 pubmed publisher
..We suggest that separation is controlled by a meiosis-specific chromosomal domain to coordinate cohesin removal and chromosome segregation. ..