Gene Symbol: haf-4
Description: HAlF transporter (PGP related)
Alias: HAlF transporter (PGP related)
Species: Caenorhabditis elegans
Schroeder L, Kremer S, Kramer M, Currie E, Kwan E, Watts J, et al
. Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle. Mol Biol Cell. 2007;18:995-1008 pubmed
..Our results provide an explanation for the loss of Nile Red-stained fat in pgp-2(-) animals as well as insight into the specialized function of this lysosome-related organelle...
Tanji T, Nishikori K, Shiraishi H, Maeda M, Ohashi Kobayashi A. Co-operative function and mutual stabilization of the half ATP-binding cassette transporters HAF-4 and HAF-9 in Caenorhabditis elegans. Biochem J. 2013;452:467-75 pubmed publisher
..The findings provide a clue as to how ABC transporters adopt a stable functional form...
Tanji T, Shiraishi H, Nishikori K, Aoyama R, Ohashi K, Maeda M, et al
. Molecular dissection of Caenorhabditis elegans ATP-binding cassette transporter protein HAF-4 to investigate its subcellular localization and dimerization. Biochem Biophys Res Commun. 2017;490:78-83 pubmed publisher
Kawai H, Tanji T, Shiraishi H, Yamada M, Iijima R, Inoue T, et al
. Normal formation of a subset of intestinal granules in Caenorhabditis elegans requires ATP-binding cassette transporters HAF-4 and HAF-9, which are highly homologous to human lysosomal peptide transporter TAP-like. Mol Biol Cell. 2009;20:2979-90 pubmed publisher
..These results demonstrate that two ABC transporters, HAF-4 and HAF-9, are related to intestinal granular formation and some other physiological aspects. ..
Tanji T, Nishikori K, Haga S, Kanno Y, Kobayashi Y, Takaya M, et al
. Characterization of HAF-4- and HAF-9-localizing organelles as distinct organelles in Caenorhabditis elegans intestinal cells. BMC Cell Biol. 2016;17:4 pubmed publisher
..Our results indicate that the HAF-4- and HAF-9-localizing organelles are distinct intestinal organelles associated with the endocytic pathway. ..