Gene Symbol: gsp-2
Description: Serine/threonine-protein phosphatase PP1-beta
Alias: Serine/threonine-protein phosphatase PP1-beta
Species: Caenorhabditis elegans
Rogers E, Bishop J, Waddle J, Schumacher J, Lin R. The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis. J Cell Biol. 2002;157:219-29 pubmed
..We propose that AIR-2 promotes the release of chromosome cohesion via phosphorylation of REC-8 at specific chromosomal locations and that CeGLC-7alpha/beta, directly or indirectly, antagonize AIR-2 activity. ..
Kaitna S, Pasierbek P, Jantsch M, Loidl J, Glotzer M. The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis. Curr Biol. 2002;12:798-812 pubmed
..Condensin mediates chromosome condensation during prophase, and condensin-independent pathways contribute to chromosome condensation during metaphase. ..
de Carvalho C, Zaaijer S, Smolikov S, Gu Y, Schumacher J, COLAIACOVO M. LAB-1 antagonizes the Aurora B kinase in C. elegans. Genes Dev. 2008;22:2869-85 pubmed publisher
..We propose that, in C. elegans, a LAB-1-mediated mechanism evolved to offset the challenges of providing protection against separase activity throughout a larger chromosome area. ..
Tzur Y, Egydio de Carvalho C, Nadarajan S, Van Bostelen I, Gu Y, Chu D, et al
. LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion. PLoS Biol. 2012;10:e1001378 pubmed publisher
Hattersley N, Cheerambathur D, Moyle M, Stefanutti M, Richardson A, Lee K, et al
. A Nucleoporin Docks Protein Phosphatase 1 to Direct Meiotic Chromosome Segregation and Nuclear Assembly. Dev Cell. 2016;38:463-77 pubmed publisher
..Thus, a pool of phosphatase activity associated with a kinetochore-localized nucleoporin contributes to two key events that occur during M-phase exit in metazoans: kinetochore disassembly and nuclear reassembly. ..
Peel N, Iyer J, Naik A, Dougherty M, Decker M, O Connell K. Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication. PLoS Genet. 2017;13:e1006543 pubmed publisher
..Our results thus define a new pathway that limits the number of daughter centrioles produced each cycle. ..
Sassa T, Ueda Ohba H, Kitamura K, Harada S, Hosono R. Role of Caenorhabditis elegans protein phosphatase type 1, CeGLC-7 beta, in metaphase to anaphase transition during embryonic development. Exp Cell Res. 2003;287:350-60 pubmed
..We propose that CeGLC-7 beta is involved in chromosome dynamics including histone H3 dephosphorylation. ..