Gene Symbol: gsp-1
Description: Serine/threonine-protein phosphatase PP1-alpha
Alias: Serine/threonine-protein phosphatase PP1-alpha
Species: Caenorhabditis elegans

Top Publications

  1. Kaitna S, Pasierbek P, Jantsch M, Loidl J, Glotzer M. The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis. Curr Biol. 2002;12:798-812 pubmed
    ..Condensin mediates chromosome condensation during prophase, and condensin-independent pathways contribute to chromosome condensation during metaphase. ..
  2. Rogers E, Bishop J, Waddle J, Schumacher J, Lin R. The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis. J Cell Biol. 2002;157:219-29 pubmed
    ..We propose that AIR-2 promotes the release of chromosome cohesion via phosphorylation of REC-8 at specific chromosomal locations and that CeGLC-7alpha/beta, directly or indirectly, antagonize AIR-2 activity. ..
  3. Bonner A, Hawley R. A Nucleoporin at the Meiotic Kinetochore. Dev Cell. 2016;38:447-8 pubmed publisher
  4. Sieburth D, Ch ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, et al. Systematic analysis of genes required for synapse structure and function. Nature. 2005;436:510-7 pubmed
    ..Twenty-four genes encoded proteins that were localized to presynaptic specializations. Loss-of-function mutations in 12 genes caused defects in presynaptic structure...
  5. Baker B, Nargund A, Sun T, Haynes C. Protective coupling of mitochondrial function and protein synthesis via the eIF2? kinase GCN-2. PLoS Genet. 2012;8:e1002760 pubmed publisher
    ..These findings are consistent with translational control and stress-dependent chaperone induction acting in complementary arms of the UPR(mt)...
  6. Tzur Y, Egydio de Carvalho C, Nadarajan S, Van Bostelen I, Gu Y, Chu D, et al. LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion. PLoS Biol. 2012;10:e1001378 pubmed publisher
  7. Peel N, Iyer J, Naik A, Dougherty M, Decker M, O Connell K. Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication. PLoS Genet. 2017;13:e1006543 pubmed publisher
    ..Our results thus define a new pathway that limits the number of daughter centrioles produced each cycle. ..