gsk-3

Summary

Gene Symbol: gsk-3
Description: Glycogen synthase kinase-3
Alias: Glycogen synthase kinase-3
Species: Caenorhabditis elegans

Top Publications

  1. Schlesinger A, Shelton C, Maloof J, Meneghini M, Bowerman B. Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell. Genes Dev. 1999;13:2028-38 pubmed
    ..Orientation of the mitotic spindle does not require gene transcription in EMS, suggesting that Wnt signaling may directly target the cytoskeleton in a responding cell. ..
  2. Gleason J, Szyleyko E, Eisenmann D. Multiple redundant Wnt signaling components function in two processes during C. elegans vulval development. Dev Biol. 2006;298:442-57 pubmed
    ..p lineage. Here, too, we found that four of five Wnt receptors can influence P7.p orientation, suggesting that a surprising amount of functional redundancy exists in Wnt signaling during C. elegans vulval induction...
  3. Walston T, Tuskey C, Edgar L, Hawkins N, Ellis G, Bowerman B, et al. Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos. Dev Cell. 2004;7:831-41 pubmed
  4. Sieburth D, Ch ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, et al. Systematic analysis of genes required for synapse structure and function. Nature. 2005;436:510-7 pubmed
    ..Twenty-four genes encoded proteins that were localized to presynaptic specializations. Loss-of-function mutations in 12 genes caused defects in presynaptic structure...
  5. Korswagen H, Coudreuse D, Betist M, van de Water S, Zivkovic D, Clevers H. The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes Dev. 2002;16:1291-302 pubmed
    ..We conclude that a highly divergent destruction complex consisting of PRY-1, SGG-1, and APR-1 regulates BAR-1/beta-catenin signaling in C. elegans. ..
  6. An J, Vranas K, Lucke M, Inoue H, Hisamoto N, Matsumoto K, et al. Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc Natl Acad Sci U S A. 2005;102:16275-80 pubmed
    ..We conclude that (i) GSK-3 inhibits SKN-1 activity in the intestine, (ii) the phase II response integrates multiple regulatory signals, and (iii), by inhibiting this response, GSK-3 may influence redox conditions. ..
  7. Nishi Y, Lin R. DYRK2 and GSK-3 phosphorylate and promote the timely degradation of OMA-1, a key regulator of the oocyte-to-embryo transition in C. elegans. Dev Biol. 2005;288:139-49 pubmed
    ..elegans. ..
  8. Shirayama M, Soto M, Ishidate T, Kim S, Nakamura K, Bei Y, et al. The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans. Curr Biol. 2006;16:47-55 pubmed
  9. Oosterveen T, Coudreuse D, Yang P, Fraser E, Bergsma J, Dale T, et al. Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans. Dev Biol. 2007;308:438-48 pubmed
    ..We conclude that Axin function in C. elegans is divided over two different Axin orthologs that have specific functions in negatively regulating canonical Wnt signaling. ..

More Information

Publications12

  1. Arur S, Ohmachi M, Nayak S, Hayes M, Miranda A, Hay A, et al. Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Proc Natl Acad Sci U S A. 2009;106:4776-81 pubmed publisher
    ..Substrates identified here have conserved orthologs in humans, suggesting that insights from these studies will contribute to our understanding of human diseases involving deregulated ERK activity. ..
  2. Tanizawa Y, Kuhara A, Inada H, Kodama E, Mizuno T, Mori I. Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans. Genes Dev. 2006;20:3296-310 pubmed
    ..These results suggest that IMPase is required in central interneurons of the mature nervous system for correct localization of synaptic components and thus for normal behavior. ..
  3. Cabello J, Neukomm L, G├╝nesdogan U, Burkart K, Charette S, Lochnit G, et al. The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. PLoS Biol. 2010;8:e1000297 pubmed publisher
    ..Taken together, our results indicate that in multiple developmental processes, CED-10/Rac can link polar signals mediated by the Wnt pathway to rearrangements of the cytoskeleton. ..