Gene Symbol: gsa 1
Description: G protein, Subunit Alpha
Alias: G protein, Subunit Alpha
Species: Caenorhabditis elegans
Govindan J, Cheng H, Harris J, Greenstein D. Galphao/i and Galphas signaling function in parallel with the MSP/Eph receptor to control meiotic diapause in C. elegans. Curr Biol. 2006;16:1257-68 pubmed
..elegans, highlighting contrasts and parallels between MSP signaling in C. elegans and luteinizing hormone signaling in mammals. ..
Govindan J, Nadarajan S, Kim S, Starich T, Greenstein D. Somatic cAMP signaling regulates MSP-dependent oocyte growth and meiotic maturation in C. elegans. Development. 2009;136:2211-21 pubmed publisher
..Our findings highlight a remarkable similarity between the regulation of meiotic resumption by soma-germline interactions in C. elegans and mammals...
Xue H, Xian B, Dong D, Xia K, Zhu S, Zhang Z, et al
. A modular network model of aging. Mol Syst Biol. 2007;3:147 pubmed
..Network simulations further suggest that aging might preferentially attack key regulatory nodes that are important for the network stability, implicating a potential molecular basis for the stochastic nature of aging. ..
Sieburth D, Ch ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, et al
. Systematic analysis of genes required for synapse structure and function. Nature. 2005;436:510-7 pubmed
..Twenty-four genes encoded proteins that were localized to presynaptic specializations. Loss-of-function mutations in 12 genes caused defects in presynaptic structure...
Mahoney T, Luo S, Round E, Brauner M, Gottschalk A, Thomas J, et al
. Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2008;105:16350-5 pubmed publisher
..We propose a model whereby the intestinal genes aex-4 and aex-5 control the DMP by regulating the secretion of a signal, which activates the neuronal receptor aex-2. ..
Fievet B, Rodriguez J, Naganathan S, Lee C, Zeiser E, Ishidate T, et al
. Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy. Nat Cell Biol. 2013;15:103-12 pubmed publisher
..Similar systematic genetic interaction screens for other biological processes will help uncover the inventory of relevant genes and their patterns of interactions. ..
Hu S, Pawson T, Steven R. UNC-73/trio RhoGEF-2 activity modulates Caenorhabditis elegans motility through changes in neurotransmitter signaling upstream of the GSA-1/Galphas pathway. Genetics. 2011;189:137-51 pubmed publisher
..Together, these data suggest UNC-73 RhoGEF-2 isoforms are required for proper neurotransmitter signaling and may function in the DCV-mediated neuromodulatory regulation of locomotion rate. ..
Syntichaki P, Samara C, Tavernarakis N. The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Curr Biol. 2005;15:1249-54 pubmed
..Similar mechanisms may contribute to necrotic cell death that follows extreme acidosis-for example, during stroke-in humans. ..
Spike C, Coetzee D, Nishi Y, Guven Ozkan T, Oldenbroek M, Yamamoto I, et al
. Translational control of the oogenic program by components of OMA ribonucleoprotein particles in Caenorhabditis elegans. Genetics. 2014;198:1513-33 pubmed publisher
..Taken together, these data support a model in which the conserved regulators of mRNA translation LIN-41 and OMA-1/2 coordinately control oocyte growth and the proper spatial and temporal execution of the meiotic maturation decision. ..