Gene Symbol: goa-1
Description: Guanine nucleotide-binding protein G(o) subunit alpha
Alias: Guanine nucleotide-binding protein G(o) subunit alpha
Species: Caenorhabditis elegans

Top Publications

  1. Colombo K, Grill S, Kimple R, Willard F, Siderovski D, GONCZY P. Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos. Science. 2003;300:1957-61 pubmed
    ..Thus, the extent of net pulling forces may depend on cortical Galpha activity, which is regulated by anterior-posterior polarity cues through GPR-1/2. ..
  2. Tsou M, Hayashi A, Rose L. LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling. Development. 2003;130:5717-30 pubmed
    ..These results provide insight into how polarity cues are transmitted into specific spindle positions in both extrinsic and intrinsic pathways of asymmetric cell division. ..
  3. Head B, Zulaika M, Ryazantsev S, van der Bliek A. A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans. Mol Biol Cell. 2011;22:831-41 pubmed publisher
    ..We conclude that MOMA-1 and IMMT-1 act in the same pathway. It is likely that the observed effects on mitochondrial diameter are an indirect effect of disrupting cristae morphology. ..
  4. Suo S, Kimura Y, Van Tol H. Starvation induces cAMP response element-binding protein-dependent gene expression through octopamine-Gq signaling in Caenorhabditis elegans. J Neurosci. 2006;26:10082-90 pubmed
    ..The results show that the endogenous octopamine system in C. elegans is activated by starvation and that different environmental stimuli can activate CREB through G alpha(q). ..
  5. Pastuhov S, Fujiki K, Nix P, Kanao S, Bastiani M, Matsumoto K, et al. Endocannabinoid-Go? signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gq?-PKC-JNK signalling. Nat Commun. 2012;3:1136 pubmed publisher
    ..Our results show that arachidonoyl ethanolamide induction of a G protein signal transduction pathway has a role in the inhibition of post-development axon regeneration...
  6. Keane J, Avery L. Mechanosensory inputs influence Caenorhabditis elegans pharyngeal activity via ivermectin sensitivity genes. Genetics. 2003;164:153-62 pubmed
  7. Hofler C, Koelle M. AGS-3 alters Caenorhabditis elegans behavior after food deprivation via RIC-8 activation of the neural G protein G ?o. J Neurosci. 2011;31:11553-62 pubmed publisher
    ..These results identify a biological role for AGS-3 in response to food deprivation and indicate the mechanism for its activation of G?(o) signaling in vivo. ..
  8. Vashlishan A, Madison J, Dybbs M, Bai J, Sieburth D, Ch ng Q, et al. An RNAi screen identifies genes that regulate GABA synapses. Neuron. 2008;58:346-61 pubmed publisher
    ..Our data suggest these conserved genes are components of signaling pathways that regulate GABA transmission and consequently may play a role in epilepsy and other cognitive or psychiatric disorders. ..
  9. Tanis J, Moresco J, Lindquist R, Koelle M. Regulation of serotonin biosynthesis by the G proteins Galphao and Galphaq controls serotonin signaling in Caenorhabditis elegans. Genetics. 2008;178:157-69 pubmed publisher

More Information


  1. Hess H, Röper J, Grill S, Koelle M. RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans. Cell. 2004;119:209-18 pubmed
    ..While GTPase activators typically inactivate G proteins, RGS-7 instead appears to promote G protein function asymmetrically in the cell, perhaps acting as a G protein effector. ..
  2. Afshar K, Willard F, Colombo K, Johnston C, McCudden C, Siderovski D, et al. RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos. Cell. 2004;119:219-30 pubmed
    ..Our findings suggest a mechanism in which RIC-8 favors generation of Galpha free from Gbetagamma and enables GPR-1/2 to mediate asymmetric cell division. ..
  3. Afshar K, Willard F, Colombo K, Siderovski D, GONCZY P. Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division. Development. 2005;132:4449-59 pubmed
  4. Govindan J, Cheng H, Harris J, Greenstein D. Galphao/i and Galphas signaling function in parallel with the MSP/Eph receptor to control meiotic diapause in C. elegans. Curr Biol. 2006;16:1257-68 pubmed
    ..elegans, highlighting contrasts and parallels between MSP signaling in C. elegans and luteinizing hormone signaling in mammals. ..
  5. Waggoner L, Hardaker L, Golik S, Schafer W. Effect of a neuropeptide gene on behavioral states in Caenorhabditis elegans egg-laying. Genetics. 2000;154:1181-92 pubmed
    ..Because flp-1 is known to be expressed in interneurons that are postsynaptic to a variety of chemosensory cells, the FLP-1 peptides may function to regulate the activity of the egg-laying circuitry in response to sensory cues. ..
  6. Cuppen E, van der Linden A, Jansen G, Plasterk R. Proteins interacting with Caenorhabditis elegans Galpha subunits. Comp Funct Genomics. 2003;4:479-91 pubmed publisher
    ..Furthermore, by means of a membrane recruitment assay, we found evidence that GPA-7 and the nuclear receptor NHR-22 can interact in the animal. ..
  7. Yamada K, Hirotsu T, Matsuki M, Kunitomo H, Iino Y. GPC-1, a G protein gamma-subunit, regulates olfactory adaptation in Caenorhabditis elegans. Genetics. 2009;181:1347-57 pubmed publisher
    ..Our analyses place goa-1 Goalpha and let-60 Ras in parallel to gpc-1. In contrast, a gain-of-function mutation in egl-30 Gqalpha was epistatic to gpc-1, suggesting the possibility that gpc-1 Ggamma may act upstream of egl-30 Gqalpha. ..
  8. Minaba M, Ichiyama S, Kojima K, Ozaki M, Kato Y. Activation of nematode G protein GOA-1 by the human muscarinic acetylcholine receptor M2 subtype. Functional coupling of G-protein-coupled receptor and G protein originated from evolutionarily distant animals. FEBS J. 2006;273:5508-16 pubmed
    ..In addition, the affinity for carbamylcholine decreased under the presence of GTP as reported for M2-G alpha(i/o) coupling. These results indicate that the M2 activates GOA-1 as well as G alpha(i/o). ..
  9. Moresco J, Koelle M. Activation of EGL-47, a Galpha(o)-coupled receptor, inhibits function of hermaphrodite-specific motor neurons to regulate Caenorhabditis elegans egg-laying behavior. J Neurosci. 2004;24:8522-30 pubmed
    ..Galpha(o) apparently integrates signaling from multiple receptors in the HSNs, including EGL-47, to set the frequency of egg-laying behavior. ..
  10. GOULDING M, Canman J, Senning E, Marcus A, Bowerman B. Control of nuclear centration in the C. elegans zygote by receptor-independent Galpha signaling and myosin II. J Cell Biol. 2007;178:1177-91 pubmed
    ..These results suggest that Galpha signaling and LET-99 control centration by regulating polarized actomyosin contraction...
  11. Srinivasan D, Fisk R, Xu H, van den Heuvel S. A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C elegans. Genes Dev. 2003;17:1225-39 pubmed
    ..Results in C. elegans and other species are consistent with a novel model for receptor-independent activation of Galpha(i/o) signaling. ..
  12. Willard F, Zheng Z, Guo J, Digby G, Kimple A, Conley J, et al. A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics. J Biol Chem. 2008;283:36698-710 pubmed publisher
    ..GoLoco motif protein complexes in microtubule dynamics and spindle function during cell division as well as to delineate potential roles for GoLoco motifs in receptor-mediated signal transduction. ..
  13. Meisel J, Panda O, Mahanti P, Schroeder F, Kim D. Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans. Cell. 2014;159:267-80 pubmed publisher
  14. Dittman J, Kaplan J. Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion. J Neurosci. 2008;28:7104-12 pubmed publisher
    ..Thus, conserved GPCRs act in the nematode motor circuit to provide negative feedback and to regulate locomotory behaviors that underlie navigation...
  15. Matsuki M, Kunitomo H, Iino Y. Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2006;103:1112-7 pubmed
    ..Our results suggest that down-regulation of EGL-30-DAG signaling by GOA-1 underlies olfactory adaptation and plasticity of chemotaxis. ..
  16. Chase D, Pepper J, Koelle M. Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans. Nat Neurosci. 2004;7:1096-103 pubmed
    ..Our results indicate that extrasynaptic dopamine regulates C. elegans locomotion through D1- and D2-like receptors that activate the antagonistic Galpha(q) and Galpha(o) signaling pathways, respectively. ..
  17. van Swinderen B, Metz L, Shebester L, Mendel J, Sternberg P, Crowder C. Goalpha regulates volatile anesthetic action in Caenorhabditis elegans. Genetics. 2001;158:643-55 pubmed
    ..elegans. Thus, the mechanism of action of VAs in C. elegans is regulated by Goalpha, and presynaptic Goalpha-effectors are candidate VA molecular targets. ..
  18. Dong M, Chase D, Patikoglou G, Koelle M. Multiple RGS proteins alter neural G protein signaling to allow C. elegans to rapidly change behavior when fed. Genes Dev. 2000;14:2003-14 pubmed
    ..Thus EGL-10 sets baseline levels of signaling, while RGS-1 and RGS-2 appear to redundantly alter signaling to cause appropriate behavioral responses to food. ..