Genomes and Genes
Gene Symbol: goa-1
Description: Guanine nucleotide-binding protein G(o) subunit alpha
Alias: Guanine nucleotide-binding protein G(o) subunit alpha
Species: Caenorhabditis elegans
- Hess H, Röper J, Grill S, Koelle M. RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans. Cell. 2004;119:209-18 pubmed..While GTPase activators typically inactivate G proteins, RGS-7 instead appears to promote G protein function asymmetrically in the cell, perhaps acting as a G protein effector. ..
- Afshar K, Willard F, Colombo K, Johnston C, McCudden C, Siderovski D, et al. RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos. Cell. 2004;119:219-30 pubmed..Our findings suggest a mechanism in which RIC-8 favors generation of Galpha free from Gbetagamma and enables GPR-1/2 to mediate asymmetric cell division. ..
- Afshar K, Willard F, Colombo K, Siderovski D, GONCZY P. Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division. Development. 2005;132:4449-59 pubmed
- Govindan J, Cheng H, Harris J, Greenstein D. Galphao/i and Galphas signaling function in parallel with the MSP/Eph receptor to control meiotic diapause in C. elegans. Curr Biol. 2006;16:1257-68 pubmed..elegans, highlighting contrasts and parallels between MSP signaling in C. elegans and luteinizing hormone signaling in mammals. ..
- Waggoner L, Hardaker L, Golik S, Schafer W. Effect of a neuropeptide gene on behavioral states in Caenorhabditis elegans egg-laying. Genetics. 2000;154:1181-92 pubmed..Because flp-1 is known to be expressed in interneurons that are postsynaptic to a variety of chemosensory cells, the FLP-1 peptides may function to regulate the activity of the egg-laying circuitry in response to sensory cues. ..
- Cuppen E, van der Linden A, Jansen G, Plasterk R. Proteins interacting with Caenorhabditis elegans Galpha subunits. Comp Funct Genomics. 2003;4:479-91 pubmed publisher..Furthermore, by means of a membrane recruitment assay, we found evidence that GPA-7 and the nuclear receptor NHR-22 can interact in the animal. ..
- Yamada K, Hirotsu T, Matsuki M, Kunitomo H, Iino Y. GPC-1, a G protein gamma-subunit, regulates olfactory adaptation in Caenorhabditis elegans. Genetics. 2009;181:1347-57 pubmed publisher..Our analyses place goa-1 Goalpha and let-60 Ras in parallel to gpc-1. In contrast, a gain-of-function mutation in egl-30 Gqalpha was epistatic to gpc-1, suggesting the possibility that gpc-1 Ggamma may act upstream of egl-30 Gqalpha. ..
- Minaba M, Ichiyama S, Kojima K, Ozaki M, Kato Y. Activation of nematode G protein GOA-1 by the human muscarinic acetylcholine receptor M2 subtype. Functional coupling of G-protein-coupled receptor and G protein originated from evolutionarily distant animals. FEBS J. 2006;273:5508-16 pubmed..In addition, the affinity for carbamylcholine decreased under the presence of GTP as reported for M2-G alpha(i/o) coupling. These results indicate that the M2 activates GOA-1 as well as G alpha(i/o). ..
- Moresco J, Koelle M. Activation of EGL-47, a Galpha(o)-coupled receptor, inhibits function of hermaphrodite-specific motor neurons to regulate Caenorhabditis elegans egg-laying behavior. J Neurosci. 2004;24:8522-30 pubmed..Galpha(o) apparently integrates signaling from multiple receptors in the HSNs, including EGL-47, to set the frequency of egg-laying behavior. ..
- GOULDING M, Canman J, Senning E, Marcus A, Bowerman B. Control of nuclear centration in the C. elegans zygote by receptor-independent Galpha signaling and myosin II. J Cell Biol. 2007;178:1177-91 pubmed..These results suggest that Galpha signaling and LET-99 control centration by regulating polarized actomyosin contraction...
- Srinivasan D, Fisk R, Xu H, van den Heuvel S. A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C elegans. Genes Dev. 2003;17:1225-39 pubmed..Results in C. elegans and other species are consistent with a novel model for receptor-independent activation of Galpha(i/o) signaling. ..
- Willard F, Zheng Z, Guo J, Digby G, Kimple A, Conley J, et al. A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics. J Biol Chem. 2008;283:36698-710 pubmed publisher..GoLoco motif protein complexes in microtubule dynamics and spindle function during cell division as well as to delineate potential roles for GoLoco motifs in receptor-mediated signal transduction. ..
- Dittman J, Kaplan J. Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion. J Neurosci. 2008;28:7104-12 pubmed publisher..Thus, conserved GPCRs act in the nematode motor circuit to provide negative feedback and to regulate locomotory behaviors that underlie navigation...
- Matsuki M, Kunitomo H, Iino Y. Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2006;103:1112-7 pubmed..Our results suggest that down-regulation of EGL-30-DAG signaling by GOA-1 underlies olfactory adaptation and plasticity of chemotaxis. ..
- Chase D, Pepper J, Koelle M. Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans. Nat Neurosci. 2004;7:1096-103 pubmed..Our results indicate that extrasynaptic dopamine regulates C. elegans locomotion through D1- and D2-like receptors that activate the antagonistic Galpha(q) and Galpha(o) signaling pathways, respectively. ..
- van Swinderen B, Metz L, Shebester L, Mendel J, Sternberg P, Crowder C. Goalpha regulates volatile anesthetic action in Caenorhabditis elegans. Genetics. 2001;158:643-55 pubmed..elegans. Thus, the mechanism of action of VAs in C. elegans is regulated by Goalpha, and presynaptic Goalpha-effectors are candidate VA molecular targets. ..
- Dong M, Chase D, Patikoglou G, Koelle M. Multiple RGS proteins alter neural G protein signaling to allow C. elegans to rapidly change behavior when fed. Genes Dev. 2000;14:2003-14 pubmed..Thus EGL-10 sets baseline levels of signaling, while RGS-1 and RGS-2 appear to redundantly alter signaling to cause appropriate behavioral responses to food. ..