Gene Symbol: glr-2
Description: Glutamate receptor 2
Alias: Glutamate receptor 2
Species: Caenorhabditis elegans

Top Publications

  1. Chang H, Rongo C. Cytosolic tail sequences and subunit interactions are critical for synaptic localization of glutamate receptors. J Cell Sci. 2005;118:1945-56 pubmed
  2. Shim J, Umemura T, Nothstein E, Rongo C. The unfolded protein response regulates glutamate receptor export from the endoplasmic reticulum. Mol Biol Cell. 2004;15:4818-28 pubmed
    ..Expression of XBP-1, a component of the UPR pathway, is elevated in neurons during development. Our results suggest that UPR signaling is a critical step in neural function that is needed for glutamate receptor assembly and secretion. ..
  3. Mellem J, Brockie P, Zheng Y, Madsen D, Maricq A. Decoding of polymodal sensory stimuli by postsynaptic glutamate receptors in C. elegans. Neuron. 2002;36:933-44 pubmed
    ..Furthermore, analysis of the EGL-3 proprotein convertase provides additional evidence that polymodal signaling in C. elegans occurs via the differential activation of postsynaptic glutamate receptor subtypes. ..
  4. Aronoff R, Mellem J, Maricq A, Sprengel R, Seeburg P. Neuronal toxicity in Caenorhabditis elegans from an editing site mutant in glutamate receptor channels. J Neurosci. 2004;24:8135-40 pubmed
    ..Thus, synaptically activated GLR-2(R)-containing iGluR channels appear to trigger inappropriate, neurotoxic Ca2+ release from intracellular stores. ..
  5. Emtage L, Chang H, Tiver R, Rongo C. MAGI-1 modulates AMPA receptor synaptic localization and behavioral plasticity in response to prior experience. PLoS ONE. 2009;4:e4613 pubmed publisher