Gene Symbol: gld-1
Description: Female germline-specific tumor suppressor gld-1
Alias: Female germline-specific tumor suppressor gld-1
Species: Caenorhabditis elegans
Products:     gld-1

Top Publications

  1. Scheckel C, Gaidatzis D, Wright J, Ciosk R. Genome-wide analysis of GLD-1-mediated mRNA regulation suggests a role in mRNA storage. PLoS Genet. 2012;8:e1002742 pubmed publisher
    ..In the absence of this protective mechanism, the accumulation of OET-promoting mRNAs, and consequently the oocyte-to-embryo transition, might be compromised. ..
  2. Ciosk R, DePalma M, Priess J. Translational regulators maintain totipotency in the Caenorhabditis elegans germline. Science. 2006;311:851-3 pubmed
  3. Ciosk R, DePalma M, Priess J. ATX-2, the C. elegans ortholog of ataxin 2, functions in translational regulation in the germline. Development. 2004;131:4831-41 pubmed
    ..Together, our results suggest that ATX-2 functions in translational regulation that is mediated by GLD-1 and MEX-3 proteins. ..
  4. Francis R, Barton M, Kimble J, Schedl T. gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans. Genetics. 1995;139:579-606 pubmed
    ..This function of gld-1 is inferred from a haplo-insufficient phenotype and from the properties of gain-of-function gld-1 mutations that cause alterations in the sexual identity of germ cells. ..
  5. Jungkamp A, Stoeckius M, Mecenas D, Grün D, Mastrobuoni G, Kempa S, et al. In vivo and transcriptome-wide identification of RNA binding protein target sites. Mol Cell. 2011;44:828-40 pubmed publisher
    ..These sites are functional in vitro and likely confer strong repression in vivo. We propose that GLD-1 interacts with the translation machinery near the start codon, a so-far-unknown mode of gene regulation in eukaryotes. ..
  6. Wright J, Gaidatzis D, Senften M, Farley B, Westhof E, Ryder S, et al. A quantitative RNA code for mRNA target selection by the germline fate determinant GLD-1. EMBO J. 2011;30:533-45 pubmed publisher
    ..This study demonstrates that transcriptome-wide identification of RBP mRNA targets combined with quantitative computational analysis can generate highly predictive models of post-transcriptional regulatory networks. ..
  7. Lehmann Blount K, Williamson J. Shape-specific nucleotide binding of single-stranded RNA by the GLD-1 STAR domain. J Mol Biol. 2005;346:91-104 pubmed
    ..Our data provide the first detailed, quantitative analysis of the STAR domain, and highlight features of STAR:RNA recognition that are distinct among single-stranded RNA-binding proteins. ..
  8. Lee M, Schedl T. Translation repression by GLD-1 protects its mRNA targets from nonsense-mediated mRNA decay in C. elegans. Genes Dev. 2004;18:1047-59 pubmed
    ..Analysis of several mRNA targets containing premature stop codons suggests that in translation repression, GLD-1 either represses ribosome assembly on the target mRNA, or subsequent ribosome elongation to the premature stop codon. ..
  9. Nayak S, Goree J, Schedl T. fog-2 and the evolution of self-fertile hermaphroditism in Caenorhabditis. PLoS Biol. 2005;3:e6 pubmed
    ..We speculate on the convergent evolution of hermaphroditism in Caenorhabditis based on the plasticity of the C. elegans germline sex determination cascade, in which multiple mutant paths yield self fertility. ..

More Information


  1. Suh N, Crittenden S, Goldstrohm A, Hook B, THOMPSON B, Wickens M, et al. FBF and its dual control of gld-1 expression in the Caenorhabditis elegans germline. Genetics. 2009;181:1249-60 pubmed publisher
    ..We propose that FBF can affect polyadenylation either negatively by its CCF-1 interaction or positively by its GLD-2 interaction. ..
  2. Mootz D, Ho D, Hunter C. The STAR/Maxi-KH domain protein GLD-1 mediates a developmental switch in the translational control of C. elegans PAL-1. Development. 2004;131:3263-72 pubmed
    ..Hence, GLD-1 mediates a developmental switch in the control of PAL-1 repression, allowing MEX-3 to accumulate and take over the task of PAL-1 repression in the proximal germline, where GLD-1 protein levels decline. ..
  3. Ryder S, Frater L, Abramovitz D, Goodwin E, Williamson J. RNA target specificity of the STAR/GSG domain post-transcriptional regulatory protein GLD-1. Nat Struct Mol Biol. 2004;11:20-8 pubmed
    ..Similarities between the SBE and the branch-site signal indicate a possible competition mechanism for STAR/GSG regulation of splicing variants. ..
  4. Hansen D, Wilson Berry L, Dang T, Schedl T. Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation. Development. 2004;131:93-104 pubmed
    ..We show that the GLD-1 accumulation pattern is important in controlling the proliferation versus meiotic development decision, with low GLD-1 levels allowing proliferation and increased levels promoting meiotic entry. ..
  5. Marin V, Evans T. Translational repression of a C. elegans Notch mRNA by the STAR/KH domain protein GLD-1. Development. 2003;130:2623-32 pubmed
    ..Furthermore, these observations indicate that precise control of GLD-1 activity by other regulatory factors is important to localize this Notch receptor, and contributes to the spatial organization of Notch signaling. ..
  6. Lee M, Schedl T. Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development. Genes Dev. 2001;15:2408-20 pubmed
    ..Previous work identified tra-2 as a GLD-1 target for germ line sex determination. Comparisons of GLD-1-mediated translational control of rme-2 and tra-2 suggests that the mechanisms may differ for distinct target mRNA species. ..
  7. Beadell A, Liu Q, Johnson D, Haag E. Independent recruitments of a translational regulator in the evolution of self-fertile nematodes. Proc Natl Acad Sci U S A. 2011;108:19672-7 pubmed publisher
    ..We conclude that, as with transcription factors, spatially localized translational regulators play important roles in the evolution of anatomical novelties. ..
  8. Carmel A, Wu J, Lehmann Blount K, Williamson J. High-affinity consensus binding of target RNAs by the STAR/GSG proteins GLD-1, STAR-2 and Quaking. BMC Mol Biol. 2010;11:48 pubmed publisher
    ..The general requirements determined for high-affinity RNA binding by STAR proteins will help facilitate the identification of novel regulatory targets in vivo. ..
  9. Beuck C, Szymczyna B, Kerkow D, Carmel A, Columbus L, Stanfield R, et al. Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation. Structure. 2010;18:377-89 pubmed publisher
    ..Finally, an improved model for STAR-mediated translational regulation of mRNA, based on the GLD-1 homodimerization domain structure, is presented. ..
  10. Schumacher B, Hanazawa M, Lee M, Nayak S, Volkmann K, Hofmann E, et al. Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. Cell. 2005;120:357-68 pubmed
    ..This study reveals that the regulation of cep-1/p53 translation influences DNA damage-induced apoptosis and demonstrates the physiological importance of this mechanism. ..
  11. Biedermann B, Wright J, Senften M, Kalchhauser I, Sarathy G, Lee M, et al. Translational repression of cyclin E prevents precocious mitosis and embryonic gene activation during C. elegans meiosis. Dev Cell. 2009;17:355-64 pubmed publisher
  12. Jones A, Francis R, Schedl T. GLD-1, a cytoplasmic protein essential for oocyte differentiation, shows stage- and sex-specific expression during Caenorhabditis elegans germline development. Dev Biol. 1996;180:165-83 pubmed
  13. Akay A, Craig A, Lehrbach N, Larance M, Pourkarimi E, Wright J, et al. RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans. Open Biol. 2013;3:130151 pubmed publisher
    ..Overall, we have uncovered genetic and biochemical interactions between GLD-1 and miRNA pathways. ..
  14. Spike C, Coetzee D, Nishi Y, Guven Ozkan T, Oldenbroek M, Yamamoto I, et al. Translational control of the oogenic program by components of OMA ribonucleoprotein particles in Caenorhabditis elegans. Genetics. 2014;198:1513-33 pubmed publisher
    ..Taken together, these data support a model in which the conserved regulators of mRNA translation LIN-41 and OMA-1/2 coordinately control oocyte growth and the proper spatial and temporal execution of the meiotic maturation decision. ..
  15. Pinkston J, Garigan D, Hansen M, Kenyon C. Mutations that increase the life span of C. elegans inhibit tumor growth. Science. 2006;313:971-5 pubmed
    ..Unexpectedly, none of these longevity mutations affected mitosis in normal germlines; this finding suggests that cellular changes that lead to longevity preferentially antagonize tumor cell growth. ..
  16. Priti A, Subramaniam K. PUF-8 Functions Redundantly with GLD-1 to Promote the Meiotic Progression of Spermatocytes in Caenorhabditis elegans. G3 (Bethesda). 2015;5:1675-84 pubmed publisher
    ..Together, results presented here uncover a novel function for gld-1 in the meiotic development of spermatocytes in both hermaphrodites and males. ..
  17. Walser C, Battu G, Hoier E, Hajnal A. Distinct roles of the Pumilio and FBF translational repressors during C. elegans vulval development. Development. 2006;133:3461-71 pubmed
    ..Thus, translational repressors regulate various aspects of vulval cell fate specification, and they may play a conserved role in modulating signal transduction during animal development. ..
  18. Jeong J, Verheyden J, Kimble J. Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans. PLoS Genet. 2011;7:e1001348 pubmed publisher
    ..Therefore, CYE-1/CDK-2 emerges as a critical regulator of stem cell maintenance. We suggest that cyclin E and Cdk-2 may be used broadly to control developmental regulators. ..
  19. Thompson B, Bernstein D, Bachorik J, Petcherski A, Wickens M, Kimble J. Dose-dependent control of proliferation and sperm specification by FOG-1/CPEB. Development. 2005;132:3471-81 pubmed
    ..The dose-dependent control of proliferation and cell fate by FOG-1 has striking parallels with Xenopus CPEB, suggesting a conserved mechanism in animal development. ..
  20. Farley B, Ryder S. POS-1 and GLD-1 repress glp-1 translation through a conserved binding-site cluster. Mol Biol Cell. 2012;23:4473-83 pubmed publisher
    ..We propose that POS-1 regulates glp-1 mRNA translation by blocking access of other RBPs to a key regulatory sequence. ..
  21. Hasegawa E, Karashima T, Sumiyoshi E, Yamamoto M. C. elegans CPB-3 interacts with DAZ-1 and functions in multiple steps of germline development. Dev Biol. 2006;295:689-99 pubmed
    ..Taken together, CPEB appears to have a conserved role in the early phase of meiosis and in the sperm/oocyte specification, in addition to its reported function during meiotic progression. ..
  22. Daubner G, Brümmer A, Tocchini C, Gerhardy S, Ciosk R, Zavolan M, et al. Structural and functional implications of the QUA2 domain on RNA recognition by GLD-1. Nucleic Acids Res. 2014;42:8092-105 pubmed publisher
    ..In conclusion, we demonstrate that the QUA2 domain distinguishes GLD-1 from other members of the STAR family and contributes more generally to the modulation of RNA-binding affinity and specificity of KH domain containing proteins. ..
  23. Beadell A, Haag E. Evolutionary Dynamics of GLD-1-mRNA complexes in Caenorhabditis nematodes. Genome Biol Evol. 2014;7:314-35 pubmed publisher
    ..Our work illustrates both the conservative and the dynamic character of evolution at the posttranslational level of gene regulation, even between congeners. ..
  24. Brenner J, Schedl T. Germline Stem Cell Differentiation Entails Regional Control of Cell Fate Regulator GLD-1 in Caenorhabditis elegans. Genetics. 2016;202:1085-103 pubmed publisher
  25. Kapelle W, Reinke V. C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival. Genesis. 2011;49:380-91 pubmed publisher
    ..Additionally, MEG activity is likely more directly involved in germ cell survival than previously thought. genesis 49:380-391, 2011. ..
  26. Garigan D, Hsu A, Fraser A, Kamath R, Ahringer J, Kenyon C. Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics. 2002;161:1101-12 pubmed
    ..Finally, we have identified a cause of death of C. elegans: namely, proliferating bacteria. This suggests that increased susceptibility to bacterial infections contributes to mortality in these animals, just as it does in humans. ..