Gene Symbol: fzy-1
Description: WD repeat-containing protein fzy-1
Alias: WD repeat-containing protein fzy-1
Species: Caenorhabditis elegans
Kitagawa R, Law E, Tang L, Rose A. The Cdc20 homolog, FZY-1, and its interacting protein, IFY-1, are required for proper chromosome segregation in Caenorhabditis elegans. Curr Biol. 2002;12:2118-23 pubmed
..IFY-1 accumulates in one-cell-arrested emb-30/APC4 embryos and interacts with SEP-1, a C. elegans separase, suggesting that IFY-1 functions as a C. elegans securin. ..
Yang H, McNally K, McNally F. MEI-1/katanin is required for translocation of the meiosis I spindle to the oocyte cortex in C elegans. Dev Biol. 2003;260:245-59 pubmed
..These results indicate a direct role of microtubule severing in translocation of the meiotic spindle to the cortex. ..
Xue H, Xian B, Dong D, Xia K, Zhu S, Zhang Z, et al
. A modular network model of aging. Mol Syst Biol. 2007;3:147 pubmed
..Network simulations further suggest that aging might preferentially attack key regulatory nodes that are important for the network stability, implicating a potential molecular basis for the stochastic nature of aging. ..
McCarthy Campbell E, Werts A, Goldstein B. A cell cycle timer for asymmetric spindle positioning. PLoS Biol. 2009;7:e1000088 pubmed publisher
Rappleye C, Tagawa A, Lyczak R, Bowerman B, Aroian R. The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation. Dev Cell. 2002;2:195-206 pubmed
..We propose that the APC/separin pathway promotes close association of the centrosome with the cortex, which in turn excludes PAR-3 from the posterior pole early in a-p axis formation. ..
Garbe D, Doto J, Sundaram M. Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8. Genetics. 2004;167:663-72 pubmed
..Loss-of-function alleles of lin-35/Rb and other SynMuv B genes suppress mat-3(ku233) defects by restoring mat-3 mRNA to wild-type levels. Therefore, Rb/E2F complexes appear to repress mat-3 expression. ..
Bezler A, GONCZY P. Mutual antagonism between the anaphase promoting complex and the spindle assembly checkpoint contributes to mitotic timing in Caenorhabditis elegans. Genetics. 2010;186:1271-83 pubmed publisher
..Taken together, our findings raise the possibility that the APC/C negatively regulates the SAC and, therefore, that the SAC and the APC/C have a mutual antagonistic relationship in C. elegans embryos. ..