Gene Symbol: ftt-2
Description: 14-3-3-like protein 2;Fourteen-Three-Three family
Alias: 14-3-3-like protein 2;Fourteen-Three-Three family
Species: Caenorhabditis elegans
Berdichevsky A, Viswanathan M, Horvitz H, Guarente L. C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell. 2006;125:1165-77 pubmed
..We propose the existence of a stress-dependent pathway in which SIR-2.1 and 14-3-3 act in parallel to the insulin-like pathway to activate DAF-16 and extend life span. ..
Li J, Tewari M, Vidal M, Lee S. The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans. Dev Biol. 2007;301:82-91 pubmed
..A similar mechanism of regulation of FOXO by 14-3-3zeta has been reported in mammalian cells, highlighting the high degree of conservation of the daf-2/insulin-like signaling pathway. ..
Wang Y, Oh S, Deplancke B, Luo J, Walhout A, Tissenbaum H. C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech Ageing Dev. 2006;127:741-7 pubmed
..Finally, we show that DAF-16/FOXO also physically interacts with the 14-3-3 proteins. These results suggest that C. elegans 14-3-3 proteins can regulate longevity by cooperating with both SIR-2.1 and DAF-16/FOXO. ..
Morton D, Shakes D, Nugent S, Dichoso D, Wang W, Golden A, et al
. The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo. Dev Biol. 2002;241:47-58 pubmed
..Our analysis indicates that the par-5 14-3-3 gene plays a crucial role in the early events leading to polarization of the C. elegans zygote. ..
Popovici C, Berda Y, Conchonaud F, Harbis A, Birnbaum D, Roubin R. Direct and heterologous approaches to identify the LET-756/FGF interactome. BMC Genomics. 2006;7:105 pubmed
..The interactors identified play various roles in developmental process or basic biochemical events such as ribosome biogenesis. ..
Heidler T, Hartwig K, Daniel H, Wenzel U. Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1. Biogerontology. 2010;11:183-95 pubmed publisher
..1-dependent alterations in gene expression after a ROS challenge lead to a lifespan extension in C. elegans as long as the stressor concentration does not exceed the saturable protective capacity. ..
Iwasa H, Maimaiti S, Kuroyanagi H, Kawano S, Inami K, Timalsina S, et al
. Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans. Exp Cell Res. 2013;319:931-45 pubmed publisher
..In short, YAP-1 partially shares basal characters with mammalian YAP and plays a role in thermal stress response and healthy aging. ..
Takahashi Y, Daitoku H, Hirota K, Tamiya H, Yokoyama A, Kako K, et al
. Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16. Cell Metab. 2011;13:505-16 pubmed publisher
..Thus, we provide a mechanism by which asymmetric arginine dimethylation acts as an antiaging modification in C. elegans. ..
Rizki G, Iwata T, Li J, Riedel C, Picard C, Jan M, et al
. The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genet. 2011;7:e1002235 pubmed publisher
..Our findings uncover a conserved interaction between the key longevity determinants SIR-2.1/SIRT1 and HCF-1, and they provide new insights into the complex regulation of FOXO proteins. ..