Gene Symbol: frk-1
Description: Fer-related kinase 1
Alias: Fer-related kinase 1
Species: Caenorhabditis elegans

Top Publications

  1. Mila D, Calderon A, Baldwin A, Moore K, Watson M, Phillips B, et al. Asymmetric Wnt Pathway Signaling Facilitates Stem Cell-Like Divisions via the Nonreceptor Tyrosine Kinase FRK-1 in Caenorhabditis elegans. Genetics. 2015;201:1047-60 pubmed publisher
    ..Overall, our data suggest a requirement for FRK-1 in maintaining the identity and proliferation of seam cells primarily through an interaction with the asymmetric Wnt pathway. ..
  2. Putzke A, Hikita S, Clegg D, Rothman J. Essential kinase-independent role of a Fer-like non-receptor tyrosine kinase in Caenorhabditis elegans morphogenesis. Development. 2005;132:3185-95 pubmed
    ..Thus, FRK-1 performs a kinase-independent function in differentiation and morphogenesis of the C. elegans epidermis during embryogenesis. ..
  3. Putzke A, Rothman J. Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase. Proc Natl Acad Sci U S A. 2010;107:16154-9 pubmed publisher
    ..These findings highlight a role for a Fer-type kinase in setting the proper levels of Wnt signaling and demonstrate the importance of this modulation in ensuring appropriate cell division. ..