Gene Symbol: fos-1
Description: Transcription factor fos-1
Alias: Transcription factor fos-1
Species: Caenorhabditis elegans
Sherwood D, Butler J, Kramer J, Sternberg P. FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans. Cell. 2005;121:951-62 pubmed
..These results reveal a key genetic network that controls basement-membrane removal during cell invasion. ..
Oommen K, Newman A. Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development. Development. 2007;134:3999-4009 pubmed
..We show that FOS-1 is expressed at pi cell specification and can bind in vitro to egl-13 upstream regulatory sequence (URS) as a heterodimer with C. elegans Jun...
Hiatt S, Duren H, Shyu Y, Ellis R, Hisamoto N, Matsumoto K, et al
. Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation. Mol Biol Cell. 2009;20:3888-95 pubmed publisher
..These findings uncover a novel role for FOS-1 and JUN-1 in the reproductive system and establish C. elegans as a model for studying AP-1 dimerization. ..
Kamikura D, Cooper J. Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Genes Dev. 2003;17:2798-811 pubmed
..These results suggest a model in which Ce-DAB-1 coordinates selection of receptors and cargo, including EGL-17, for transport through the secretory pathway. ..
Sapir A, Choi J, Leikina E, Avinoam O, Valansi C, Chernomordik L, et al
. AFF-1, a FOS-1-regulated fusogen, mediates fusion of the anchor cell in C. elegans. Dev Cell. 2007;12:683-98 pubmed
..Thus, FOS-1 links cell invasion and fusion in a developmental cascade. ..
Uno M, Honjoh S, Matsuda M, Hoshikawa H, Kishimoto S, Yamamoto T, et al
. A fasting-responsive signaling pathway that extends life span in C. elegans. Cell Rep. 2013;3:79-91 pubmed publisher
..Our results thus identify a fasting-responsive KGB-1/AP-1 signaling pathway, which, together with DAF-16, causes transcriptional changes that mediate longevity, partly through regulating proteostasis. ..
Hattori A, Mizuno T, Akamatsu M, Hisamoto N, Matsumoto K. The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex. PLoS Genet. 2013;9:e1003315 pubmed publisher
..This study describes the direct link from JNK signaling, Fos phosphorylation, and regulation of kreg gene transcription, which modulates the stress response in C. elegans...
Wang Z, Chi Q, Sherwood D. MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans. Development. 2014;141:1342-53 pubmed publisher
..These studies indicate that MIG-10 has distinct functions from UNC-40 signaling in cell invasion, and demonstrate that integrin coordinates invasion by localizing these molecules to the cell-basement membrane interface. ..
Zhang Z, Liu L, Twumasi Boateng K, Block D, Shapira M. FOS-1 functions as a transcriptional activator downstream of the C. elegans JNK homolog KGB-1. Cell Signal. 2017;30:1-8 pubmed publisher