Gene Symbol: fog 2
Description: Feminization Of Germline
Alias: Feminization Of Germline
Species: Caenorhabditis elegans
Clifford R, Lee M, Nayak S, Ohmachi M, Giorgini F, Schedl T. FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline. Development. 2000;127:5265-76 pubmed
..fog-2 may have arisen during evolution of self-fertile hermaphroditism from an ancestral female/male species. ..
Spike C, Coetzee D, Nishi Y, Guven Ozkan T, Oldenbroek M, Yamamoto I, et al
. Translational control of the oogenic program by components of OMA ribonucleoprotein particles in Caenorhabditis elegans. Genetics. 2014;198:1513-33 pubmed publisher
..Taken together, these data support a model in which the conserved regulators of mRNA translation LIN-41 and OMA-1/2 coordinately control oocyte growth and the proper spatial and temporal execution of the meiotic maturation decision. ..
Ciosk R, DePalma M, Priess J. ATX-2, the C. elegans ortholog of ataxin 2, functions in translational regulation in the germline. Development. 2004;131:4831-41 pubmed
..Together, our results suggest that ATX-2 functions in translational regulation that is mediated by GLD-1 and MEX-3 proteins. ..
Gissendanner C, Kelley K, Nguyen T, Hoener M, Sluder A, Maina C. The Caenorhabditis elegans NR4A nuclear receptor is required for spermatheca morphogenesis. Dev Biol. 2008;313:767-86 pubmed
..elegans hermaphrodites. The phenotypes of nhr-6(lg6001) mutants are consistent with a role for nhr-6 in organogenesis, similar to the functions of its mammalian homologs. ..
Narbonne P, Maddox P, LabbÃ© J. DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans. Development. 2015;142:4230-41 pubmed publisher
..Thus, during adulthood, stem cells can differentially respond within tissues to otherwise equal insulin/IGF-1 signalling inputs, according to the needs for production of their immediate terminally differentiated progeny. ..
Nayak S, Goree J, Schedl T. fog-2 and the evolution of self-fertile hermaphroditism in Caenorhabditis. PLoS Biol. 2005;3:e6 pubmed
..We speculate on the convergent evolution of hermaphroditism in Caenorhabditis based on the plasticity of the C. elegans germline sex determination cascade, in which multiple mutant paths yield self fertility. ..
Rane H, Smith J, Bergthorsson U, Katju V. Gene conversion and DNA sequence polymorphism in the sex-determination gene fog-2 and its paralog ftr-1 in Caenorhabditis elegans. Mol Biol Evol. 2010;27:1561-9 pubmed publisher