Gene Symbol: flp-21
Description: FMRF-Like Peptide
Alias: FMRF-Like Peptide
Species: Caenorhabditis elegans

Top Publications

  1. Kubiak T, Larsen M, Nulf S, Zantello M, Burton K, Bowman J, et al. Differential activation of "social" and "solitary" variants of the Caenorhabditis elegans G protein-coupled receptor NPR-1 by its cognate ligand AF9. J Biol Chem. 2003;278:33724-9 pubmed
    ..Since neuropeptide Y shows no sequence homology to AF9 and was functionally inactive at the cloned NPR-1, we propose to rename NPR-1 and refer to it as an AF9 receptor, AF9-R1. ..
  2. Rogers C, Reale V, Kim K, Chatwin H, Li C, Evans P, et al. Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1. Nat Neurosci. 2003;6:1178-85 pubmed
    ..elegans. Our data suggest a model in which solitary feeding evolved in an ancestral social strain of C. elegans by a gain-of-function mutation that modified the response of NPR-1 to FLP-18 and FLP-21 ligands. ..
  3. Glauser D, Chen W, Agin R, MacInnis B, Hellman A, Garrity P, et al. Heat avoidance is regulated by transient receptor potential (TRP) channels and a neuropeptide signaling pathway in Caenorhabditis elegans. Genetics. 2011;188:91-103 pubmed publisher
    ..Our results show that TRPV channels and the FLP-21/NPR-1 neuropeptide signaling pathway determine the threshold for heat avoidance in C. elegans. ..