Gene Symbol: flp-11
Description: SPLDEEDFAPESPLQ-amide
Species: Caenorhabditis elegans

Top Publications

  1. Mertens I, Clinckspoor I, Janssen T, Nachman R, Schoofs L. FMRFamide related peptide ligands activate the Caenorhabditis elegans orphan GPCR Y59H11AL.1. Peptides. 2006;27:1291-6 pubmed
    ..Indeed, we found that the orphan receptor encoded by the Y59H11AL.1 gene is activated by several C. elegans neuropeptides, including SPMERSAMVRFamide. These peptides activate the receptor in a concentration-dependent way. ..
  2. Turek M, Besseling J, Spies J, König S, Bringmann H. Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep. elife. 2016;5: pubmed publisher
    ..Surprisingly FLP-11, and not GABA, is the major component that determines the sleep-promoting function of RIS. FLP-11 is constantly expressed in RIS. At sleep onset RIS depolarizes and releases FLP-11 to induce a systemic sleep state. ..
  3. Banerjee N, Bhattacharya R, Gorczyca M, Collins K, Francis M. Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior. PLoS Genet. 2017;13:e1006697 pubmed publisher