flp 1


Gene Symbol: flp 1
Description: SQPNFLRF-amide
Alias: SQPNFLRF-amide
Species: Caenorhabditis elegans

Top Publications

  1. Nelson L, Rosoff M, Li C. Disruption of a neuropeptide gene, flp-1, causes multiple behavioral defects in Caenorhabditis elegans. Science. 1998;281:1686-90 pubmed
    ..These results demonstrate that varying the levels of FLP-1 neuropeptides can profoundly affect behavior and that members of this large neuropeptide gene family are not functionally redundant in C. elegans. ..
  2. Waggoner L, Hardaker L, Golik S, Schafer W. Effect of a neuropeptide gene on behavioral states in Caenorhabditis elegans egg-laying. Genetics. 2000;154:1181-92 pubmed
    ..Because flp-1 is known to be expressed in interneurons that are postsynaptic to a variety of chemosensory cells, the FLP-1 peptides may function to regulate the activity of the egg-laying circuitry in response to sensory cues. ..
  3. Mertens I, Clinckspoor I, Janssen T, Nachman R, Schoofs L. FMRFamide related peptide ligands activate the Caenorhabditis elegans orphan GPCR Y59H11AL.1. Peptides. 2006;27:1291-6 pubmed
    ..Indeed, we found that the orphan receptor encoded by the Y59H11AL.1 gene is activated by several C. elegans neuropeptides, including SPMERSAMVRFamide. These peptides activate the receptor in a concentration-dependent way. ..
  4. Stawicki T, Takayanagi Kiya S, Zhou K, Jin Y. Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans. PLoS Genet. 2013;9:e1003472 pubmed publisher