Genomes and Genes
Gene Symbol: fbf-2
Description: Fem-3 mRNA-binding factor 2
Alias: Fem-3 mRNA-binding factor 2
Species: Caenorhabditis elegans
- Wu J, Campbell Z, Menichelli E, Wickens M, Williamson J. A protein.protein interaction platform involved in recruitment of GLD-3 to the FBF.fem-3 mRNA complex. J Mol Biol. 2013;425:738-54 pubmed publisher..These data raise the possibility of alternative models involving the formation of a GLD-3?FBF?RNA complex in the regulation of germline mRNAs. ..
- Merritt C, Seydoux G. The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the expression of synaptonemal complex proteins in germline stem cells. Development. 2010;137:1787-98 pubmed publisher..We propose that parallel regulation by FBF ensures that in wild-type gonads, meiotic entry is coordinated with just-in-time synthesis of synaptonemal proteins...
- Menichelli E, Wu J, Campbell Z, Wickens M, Williamson J. Biochemical characterization of the Caenorhabditis elegans FBF.CPB-1 translational regulation complex identifies conserved protein interaction hotspots. J Mol Biol. 2013;425:725-37 pubmed publisher..RNA binding measurements demonstrated that CPB-1 alters the affinity of FBF for specific RNA sequences, implying a functional model where the coregulatory protein CPB-1 modulates FBF target selection. ..
- Voronina E, Paix A, Seydoux G. The P granule component PGL-1 promotes the localization and silencing activity of the PUF protein FBF-2 in germline stem cells. Development. 2012;139:3732-40 pubmed..Our findings also support the view that P granules facilitate mRNA silencing by providing an environment in which translational repressors can encounter their mRNA targets immediately upon exit from the nucleus. ..