fat-2

Summary

Gene Symbol: fat-2
Description: Delta(12) fatty acid desaturase fat-2;FATty acid desaturase
Alias: Delta(12) fatty acid desaturase fat-2;FATty acid desaturase
Species: Caenorhabditis elegans

Top Publications

  1. Watts J, Browse J. Genetic dissection of polyunsaturated fatty acid synthesis in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2002;99:5854-9 pubmed
    ..However, mutants with more severe PUFA deficiencies display growth and neurological defects. The mutants provide tools for investigating the roles of PUFAs in membrane biology and cell function in this animal model. ..
  2. Peyou Ndi M, Watts J, Browse J. Identification and characterization of an animal delta(12) fatty acid desaturase gene by heterologous expression in Saccharomyces cerevisiae. Arch Biochem Biophys. 2000;376:399-408 pubmed
  3. Yuan Y, Kadiyala C, Ching T, Hakimi P, Saha S, Xu H, et al. Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans. J Biol Chem. 2012;287:31414-26 pubmed publisher
    ..We conclude that an increase, not a decrease in fuel consumption, via an accelerated oxidation of fuels in the TCA cycle is involved in life span regulation; this mechanism may be conserved across phylogeny. ..
  4. Sasata R, Reed D, Loewen M, Covello P. Domain swapping localizes the structural determinants of regioselectivity in membrane-bound fatty acid desaturases of Caenorhabditis elegans. J Biol Chem. 2004;279:39296-302 pubmed
    ..In this way, the structural determinants of regioselectivity in FAT-1 and FAT-2 have been localized to two interdependent regions: a relatively hydrophobic region between the first two histidine boxes and the carboxyl-terminal region. ..
  5. Horikawa M, Nomura T, Hashimoto T, Sakamoto K. Elongation and desaturation of fatty acids are critical in growth, lipid metabolism and ontogeny of Caenorhabditis elegans. J Biochem. 2008;144:149-58 pubmed publisher
    ..These results indicated that the elongation and desaturation of fatty acids are integral to various phenomena such as ontogeny and lifespan and play important roles in fatty acid accumulation and consumption. ..
  6. Nandakumar M, Tan M. Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity. PLoS Genet. 2008;4:e1000273 pubmed publisher
    ..The conservation of p38 MAP kinase signaling in both stress and immune responses further encourages exploring the function of GLA and SDA in humans. ..
  7. Zhou X, Green A, Singh S. Caenorhabditis elegans Delta12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the Delta12 and Delta15 positions. J Biol Chem. 2011;286:43644-50 pubmed publisher
    ..elegans ?12-desaturase CeFAT-2 might have arisen independently from other reported dual ?12/?15-desaturases from fungi and protozoa. ..