F59G1.6

Summary

Gene Symbol: F59G1.6
Description: miscRNA
Species: Caenorhabditis elegans

Top Publications

  1. ncbi Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity
    Lorenzo F Sempere
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Dev Biol 259:9-18. 2003
  2. pmc The lin-4 microRNA targets the LIN-14 transcription factor to inhibit netrin-mediated axon attraction
    Yan Zou
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Sci Signal 5:ra43. 2012
  3. ncbi An extensive class of small RNAs in Caenorhabditis elegans
    R C Lee
    Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
    Science 294:862-4. 2001
  4. ncbi Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    A Grishok
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 106:23-34. 2001
  5. ncbi Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
    A E Pasquinelli
    Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Nature 408:86-9. 2000
  6. ncbi The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target
    Shin Yi Lin
    Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, CT 06520, USA
    Dev Cell 4:639-50. 2003
  7. ncbi Anomalous RNA substrates for mammalian tRNA 3' processing endoribonuclease
    M Nashimoto
    Life Science Research Laboratory, JT, Yokohama, Kanagawa, Japan
    FEBS Lett 472:179-86. 2000
  8. ncbi The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    B J Reinhart
    Department of Molecular Biology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Nature 403:901-6. 2000
  9. pmc Structure and function analysis of LIN-14, a temporal regulator of postembryonic developmental events in Caenorhabditis elegans
    Y Hong
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Mol Cell Biol 20:2285-95. 2000
  10. ncbi The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
    P H Olsen
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Dev Biol 216:671-80. 1999

Scientific Experts

  • GARY B RUVKUN
  • Victor Ambros
  • Eric G Moss
  • M Nashimoto
  • Yan Zou
  • A E Pasquinelli
  • Steven M Johnson
  • Shin Yi Lin
  • Xavier C Ding
  • R C Lee
  • A E Rougvie
  • B J Reinhart
  • Michelle Boehm
  • Rosalind Lee
  • Frank Slack
  • Frank J Slack
  • I Ha
  • Lorenzo F Sempere
  • Arash Bashirullah
  • Kathy Seggerson
  • Diya Banerjee
  • F Slack
  • J C Bettinger
  • Chiou Fen Chuang
  • Hui Chiu
  • A Grishok
  • Chieh Chang
  • Dorothée Domenger
  • Y Hong
  • Helge Grosshans
  • P H Olsen
  • R Feinbaum
  • J E Abrahante
  • Rhonda Feinbaum
  • F Liu
  • Amy E Pasquinelli
  • Chiara Gamberi
  • Mary Abraham
  • Ellen Gottlieb
  • Nicholas S Sokol
  • Monica C Vella
  • Carl S Thummel
  • Amy Pasquinelli
  • Norbert Perrimon
  • Edward M Berger
  • H R Horvitz
  • Amy A Kiger
  • Edward B Dubrovsky
  • B Wightman
  • S Euling
  • Lingjuan Tang
  • C C Mello
  • D L Baillie
  • N Li
  • D Conte
  • S Parrish
  • A Fire
  • B Maller
  • M I Kuroda
  • F J Slack
  • A Srinivasan
  • J Spring
  • M Levine
  • B Degnan
  • E E Ball
  • N Delihas
  • M Fishman
  • P Leahy
  • Z Liu
  • M Q Martindale
  • P Muller
  • J Finnerty
  • D C Hayward
  • E Davidson
  • M Basson
  • J Corbo
  • J Austin
  • E A Miller
  • J D Thatcher
  • H F Epstein
  • K Lee
  • S Mitani
  • S Kirch
  • C Kenyon
  • D H Hall
  • J E Sulston
  • H Du
  • M Driscoll
  • R L Feinbaum
  • M Chalfie

Detail Information

Publications45

  1. ncbi Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity
    Lorenzo F Sempere
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Dev Biol 259:9-18. 2003
    ....
  2. pmc The lin-4 microRNA targets the LIN-14 transcription factor to inhibit netrin-mediated axon attraction
    Yan Zou
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Sci Signal 5:ra43. 2012
    ..LIN-14 stimulated UNC-6-mediated axon attraction in part by increasing UNC-40 abundance. Our study indicated that lin-4 microRNA reduced the activity of LIN-14 to terminate UNC-6-mediated axon guidance of AVM neurons...
  3. ncbi An extensive class of small RNAs in Caenorhabditis elegans
    R C Lee
    Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
    Science 294:862-4. 2001
    ..elegans larval development, and three of them have apparent homologs in mammals and/or insects. Small noncoding RNAs of the miRNA class appear to be numerous and diverse...
  4. ncbi Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    A Grishok
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 106:23-34. 2001
    ..Our findings suggest that a common processing machinery generates guide RNAs that mediate both RNAi and endogenous gene regulation...
  5. ncbi Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
    A E Pasquinelli
    Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Nature 408:86-9. 2000
    ..elegans and Drosophila, at 48 hours after fertilization in zebrafish, and in adult stages of annelids and molluscs. The let-7 regulatory RNA may control late temporal transitions during development across animal phylogeny...
  6. ncbi The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target
    Shin Yi Lin
    Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, CT 06520, USA
    Dev Cell 4:639-50. 2003
    ..MicroRNAs may likewise function to regulate Drosophila hunchback during temporal patterning of the nervous system...
  7. ncbi Anomalous RNA substrates for mammalian tRNA 3' processing endoribonuclease
    M Nashimoto
    Life Science Research Laboratory, JT, Yokohama, Kanagawa, Japan
    FEBS Lett 472:179-86. 2000
    ..We also demonstrated that an RNA complex of lin-4 and lin-14 from Caenorhabditis elegans can be recognized and cleaved by pig 3' tRNase...
  8. ncbi The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    B J Reinhart
    Department of Molecular Biology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Nature 403:901-6. 2000
    ..We propose that the sequential stage-specific expression of the lin-4 and let-7 regulatory RNAs triggers transitions in the complement of heterochronic regulatory proteins to coordinate developmental timing...
  9. pmc Structure and function analysis of LIN-14, a temporal regulator of postembryonic developmental events in Caenorhabditis elegans
    Y Hong
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Mol Cell Biol 20:2285-95. 2000
    ..These results support the view that LIN-14 controls developmental timing in C. elegans by regulating gene expression in the nucleus...
  10. ncbi The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
    P H Olsen
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Dev Biol 216:671-80. 1999
    ....
  11. ncbi The timing of lin-4 RNA accumulation controls the timing of postembryonic developmental events in Caenorhabditis elegans
    R Feinbaum
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA
    Dev Biol 210:87-95. 1999
    ..These results indicate that the temporal profile of lin-4 RNA accumulation specifies the timing of LIN-14 down-regulation and thereby controls the timing of postembryonic developmental events...
  12. ncbi Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression
    Diya Banerjee
    Department of Molecular, Cellular and Development Biology, Yale University, 266 Whitney Ave, New Haven, CT 06520, USA
    Bioessays 24:119-29. 2002
    ..We postulate that other small non-coding RNAs may function as stRNAs to control temporal identity during development in C. elegans and other organisms...
  13. ncbi Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation
    Kathy Seggerson
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Dev Biol 243:215-25. 2002
    ..The role of lin-4 may be to initiate or potentiate the lin-4-independent circuit. We speculate that a parallel lin-4-independent regulatory mechanism regulates the expression of lin-14...
  14. pmc Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins
    Xavier C Ding
    Friedrich Miescher Institute for Biomedical Research FMI, Basel, Switzerland
    EMBO J 28:213-22. 2009
    ..elegans as a genetic system for dissection of the underlying mechanisms...
  15. ncbi A developmental timing microRNA and its target regulate life span in C. elegans
    Michelle Boehm
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
    Science 310:1954-7. 2005
    ..This work reveals a role for microRNAs and developmental timing genes in life-span regulation...
  16. ncbi The 20 years it took to recognize the importance of tiny RNAs
    Gary Ruvkun
    Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Fruit Street, Boston, Massachusetts 02114, USA
    Cell 116:S93-6, 2 p following S96. 2004
  17. ncbi A short history of a short RNA
    Rosalind Lee
    Department of Genetics Dartmouth Medical School Hanover, New Hampshire 03755, USA
    Cell 116:S89-92, 1 p following S96. 2004
  18. ncbi The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter
    Steven M Johnson
    Department of Molecular, Cellular, and Developmental Biology, Yale University, P O Box 208103, New Haven, CT 06520 8103, USA
    Dev Biol 259:364-79. 2003
    ..We speculate that these heterochronic genes regulate let-7 expression through its TRE...
  19. ncbi Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis
    Arash Bashirullah
    Howard Hughes Medical Institute, Department of Human Genetics, 15 North 2030 East Room 5100, University of Utah, Salt Lake City, UT 84112 5331, USA
    Dev Biol 259:1-8. 2003
    ..We conclude that a common precursor RNA containing both let-7 and miR-125 is induced independently of ecdysone in Drosophila, raising the possibility of a temporal signal that is distinct from the well-characterized ecdysone-EcR pathway...
  20. ncbi MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
    Cell 113:673-6. 2003
    ..In C. elegans, a homolog of the well-known fly developmental regulator hunchback acts downstream of the microRNAs lin-4 and let-7 in a pathway controlling developmental timing...
  21. ncbi Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites
    Eric G Moss
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Dev Biol 258:432-42. 2003
    ..elegans lin-4 and let-7 microRNAs, suggesting that microRNA regulation is a conserved feature of the Lin-28 gene in diverse animals...
  22. pmc Identification of heterochronic mutants in Caenorhabditis elegans. Temporal misexpression of a collagen::green fluorescent protein fusion gene
    J E Abrahante
    Department of Genetics and Cell Biology, University of Minnesota, St Paul, Minnesota 55108, USA
    Genetics 149:1335-51. 1998
    ..Two mutations define a new gene, lin-58. When separated from lin-4, the lin-58 mutations cause precocious seam cell terminal differentiation and thus define a new member of the heterochronic gene pathway...
  23. ncbi Temporal pattern formation by heterochronic genes
    F Slack
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Annu Rev Genet 31:611-34. 1997
    ..Hormonal control of developmental timing is a common theme throughout phylogeny. Heterochronic genes that involve hormonal signaling have been identified in vertebrates as well as C. elegans...
  24. ncbi The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA
    E G Moss
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Cell 88:637-46. 1997
    ..Deleting the LCE produces a dominant gain-of-function allele that causes a retarded phenotype, indicating that lin-28 activity is a switch that controls choices of stage-specific fates...
  25. ncbi Regulation of gene expression by trans-encoded antisense RNAs
    N Delihas
    Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York, Stony Brook 11794 5222, USA
    Mol Microbiol 15:411-4. 1995
    ..It is possible that currently known unlinked antisense RNA genes are part of a larger class of heretofore undiscovered regulatory RNA genes. Possible ways of detecting other unlinked antisense RNA genes are discussed...
  26. pmc Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans
    H R Horvitz
    Genetics 96:435-54. 1980
    ..Three of the mutants are suppressed by pleiotropic suppressors believed to be specific for null alleles, suggesting that their phenotypes result from the complete absence of gene activity...
  27. ncbi Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans
    J E Sulston
    Dev Biol 82:41-55. 1981
  28. ncbi A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans
    V Ambros
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138
    Cell 57:49-57. 1989
    ..lin-29 may activate the L/A switch by regulating genes that control cell division, differentiation, and stage-specific gene expression in hypodermal cells...
  29. ncbi Heterochronic genes control the stage-specific initiation and expression of the dauer larva developmental program in Caenorhabditis elegans
    Z C Liu
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138
    Genes Dev 3:2039-49. 1989
    ..Our results further suggest that dauer larva morphogenesis by hypodermal cells requires that lin-28 acts to inhibit lin-29 during early larval stages...
  30. ncbi Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28
    P Arasu
    Department of Molecular Biology, Massachusetts General Hospital, Boston
    Genes Dev 5:1825-33. 1991
    ..Switching off lin-14 expression during the L1 stage is not triggered by the passage of time per se but, rather, is normally dependent on feeding or the feeding-dependent initiation of postembryonic cell division...
  31. ncbi The Caenorhabditis elegans heterochronic gene pathway controls stage-specific transcription of collagen genes
    Z Liu
    Harvard University Department of Cellular and Developmental Biology, Cambridge, MA 02138, USA
    Development 121:2471-8. 1995
    ..These findings indicate that the heterochronic gene pathway regulates the timing of hypodermal cell terminal differentiation by regulating larval- and adult-specific gene expression, perhaps by the direct action of lin-29...
  32. ncbi The heterochronic gene lin-29 encodes a zinc finger protein that controls a terminal differentiation event in Caenorhabditis elegans
    A E Rougvie
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Development 121:2491-500. 1995
    ..lin-29 mRNA is detected in the first larval stage and increases in abundance through subsequent larval stages until the final molt, when lin-29 activity is required for terminal differentiation...
  33. ncbi Induction of glyoxylate cycle expression in Caenorhabditis elegans: a fasting response throughout larval development
    F Liu
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochemistry 36:255-60. 1997
    ....
  34. ncbi A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation
    I Ha
    Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Genes Dev 10:3041-50. 1996
    ..This suggests that a specific secondary structure of lin-4/lin-14 RNA duplex that may be recognized by an accessory protein, rather than an RNA duplex per se, is required in vivo for the generation of the LIN-14 temporal gradient...
  35. ncbi Stage-specific accumulation of the terminal differentiation factor LIN-29 during Caenorhabditis elegans development
    J C Bettinger
    Department of Genetics and Cell Biology, University of Minnesota, St Paul 55108, USA
    Development 122:2517-27. 1996
    ..LIN-29 also accumulates stage-specifically in the nuclei of a variety of non-hypodermal cells during development. Its accumulation is dependent upon the upstream heterochronic genes in some, but not all, of these non-hypodermal cells...
  36. ncbi Heterochronic genes control cell cycle progress and developmental competence of C. elegans vulva precursor cells
    S Euling
    Department of Cellular and Developmental Biology, Harvard University Cambridge, Massachusetts 02138, USA
    Cell 84:667-76. 1996
    ..A genetic pathway that includes lin-4, lin-14, and lin-28 controls when VPCs complete G1 and also controls when VPCs acquire the competence to respond to the intercellular patterning signals and express vulval fates...
  37. ncbi Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    B Wightman
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Cell 75:855-62. 1993
    ..These data suggest a molecular mechanism for Lin-14p temporal gradient formation: the lin-4 RNAs base pair to sites in the lin-14 3'UTR to form multiple RNA duplexes that down-regulate lin-14 translation...
  38. ncbi The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    R C Lee
    Harvard University, Department of Cellular and Developmental Biology, Cambridge, Massachusetts 02138
    Cell 75:843-54. 1993
    ..elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin-4 regulates lin-14 translation via an antisense RNA-RNA interaction...
  39. ncbi Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans
    S Mitani
    Department of Biological Sciences, Columbia University, New York, NY 10027
    Development 119:773-83. 1993
    ....
  40. ncbi Heterochronic genes and the temporal control of C. elegans development
    V Ambros
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755
    Trends Genet 10:123-7. 1994
    ....
  41. ncbi Developmental timekeeping. Marking time with antisense
    J Austin
    Department of Biochemistry, UCSF 94143 0554
    Curr Biol 4:366-9. 1994
    ..Post-transcriptional regulation of the heterochronic gene lin-14 by the binding of a natural antisense RNA controls the temporal pattern of larval development in the nematode Caenorhabditis elegans...
  42. ncbi Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes
    G Ruvkun
    Department of Molecular Biology, Massachusetts General Hospital, Boston
    Dev Suppl 1:47-54. 1991
    ..The normal down-regulation of lin-14 within 10 h of hatching is not determined by the passage of time per se, but rather is triggered when feeding induces post-embryonic development.(ABSTRACT TRUNCATED AT 250 WORDS)..

Research Grants40

  1. GENETIC AND MOLECULAR BASIS OF LONGEVITY
    Gary Ruvkun; Fiscal Year: 2003
    ..Thus human DAF-16 may become a major target for pharmaceutical development of diabetes therapies. ..
  2. Genomic analysis of C. elegans fat regulatory pathways
    Gary Ruvkun; Fiscal Year: 2007
    ..elegans is amenable to large scale genetic and functional genomic screens which is not feasible in mice. Therefore, identification of tub pathway genes in C. elegans may provide targets for intervention of obesity in human. ..
  3. Inositol Signaling in C. elegans Senescence and Diapause
    Gary Ruvkun; Fiscal Year: 2007
    ..The products of the genes we have identified may be targets for pharmaceutical development of diabetes therapies. ..
  4. GENETIC AND MOLECULAR BASIS OF LONGEVITY
    Gary Ruvkun; Fiscal Year: 2007
    ..The products of the genes we have identified may be targets for pharmaceutical development of diabetes therapies. ..
  5. Control of C. elegans Lineage by Heterochronic Genes
    Gary Ruvkun; Fiscal Year: 2007
    ..We will also genetically study the process by which RNAi is negatively regulated. We will explore whether miRNAs can act as signals between cells. ..
  6. GENETIC AND MOLECULAR BASIS OF LONGEVITY
    GARY B RUVKUN; Fiscal Year: 2010
    ..In some cases, the genes encode proteins that are attractive for the development of drugs. Therefore, identification of aging pathway genes in C. elegans provides targets for intervention of human aging. ..
  7. Genomic analysis of C. elegans fat regulatory pathways
    GARY B RUVKUN; Fiscal Year: 2010
    ..The studies of obesity in C. elegans is likely to identify targets for intervention of obesity in human. ..
  8. Control of C. elegans Lineage by Heterochronic Genes
    GARY B RUVKUN; Fiscal Year: 2010
    ..The genes identified in this study are likely to be key factors in the function of small RNAs in biology and thus their identification may enable more potent RNAi based drug development. ..
  9. CONTROL OF THE C ELEGANS LINEAGE BY HETEROCHRONIC GENES
    Gary Ruvkun; Fiscal Year: 1993
    ..Mutations in these human temporal control genes may be the molecular basis for some human genetic diseases (for example, particular cancers) that lead to temporal transformations in cell fate...
  10. CONTROL OF C.ELEGANS LINEAGE BY HETEROCHRONIC GENES
    Gary Ruvkun; Fiscal Year: 2003
    ..abstract_text> ..
  11. Genomic analysis of C. elegans fat regulatory pathways
    GARY B RUVKUN; Fiscal Year: 2010
    ..The studies of obesity in C. elegans is likely to identify targets for intervention of obesity in human. ..