ero-1

Summary

Gene Symbol: ero-1
Description: Endoplasmic Reticulum Oxidase;Endoplasmic reticulum oxidoreductin-1
Alias: Endoplasmic Reticulum Oxidase;Endoplasmic reticulum oxidoreductin-1
Species: Caenorhabditis elegans

Top Publications

  1. Harding H, Zhang Y, Zeng H, Novoa I, Lu P, Calfon M, et al. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell. 2003;11:619-33 pubmed
    ..A signaling pathway initiated by eIF2alpha phosphorylation protects cells against metabolic consequences of ER oxidation by promoting the linked processes of amino acid sufficiency and resistance to oxidative stress. ..
  2. Marciniak S, Yun C, Oyadomari S, Novoa I, Zhang Y, Jungreis R, et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 2004;18:3066-77 pubmed
    ..CHOP deletion thus protects cells from ER stress by decreasing ER client protein load and changing redox conditions within the organelle. ..