eri-3

Summary

Gene Symbol: eri-3
Description: Enhanced RNAI (RNA interference)
Alias: Enhanced RNAI (RNA interference)
Species: Caenorhabditis elegans

Top Publications

  1. Argon Y, Ward S. Caenorhabditis elegans fertilization-defective mutants with abnormal sperm. Genetics. 1980;96:413-33 pubmed
    ..This set of mutants provides a variety of functional and structural alterations in nematode sperm that should help identify and analyze gene products involved in sperm morphogenesis and motility. ..
  2. Pavelec D, Lachowiec J, Duchaine T, Smith H, Kennedy S. Requirement for the ERI/DICER complex in endogenous RNA interference and sperm development in Caenorhabditis elegans. Genetics. 2009;183:1283-95 pubmed publisher
  3. Zhuang J, Hunter C. Tissue specificity of Caenorhabditis elegans enhanced RNA interference mutants. Genetics. 2011;188:235-7 pubmed publisher
    ..Enhanced RNAi (Eri) mutants facilitate RNAi due to their hypersensitivity to dsRNA. Here, we compare eight Eri mutants for sensitivity to ingested dsRNA, targeting a variety of tissue-specific genes. ..
  4. Thivierge C, Makil N, Flamand M, Vasale J, Mello C, Wohlschlegel J, et al. Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi. Nat Struct Mol Biol. 2011;19:90-7 pubmed publisher
    ..Our results implicate tudor proteins in the recruitment of RdRP complexes to specific steps within DCR-1-dependent and DCR-1-independent endo-RNAi pathways. ..
  5. Duchaine T, Wohlschlegel J, Kennedy S, Bei Y, Conte D, Pang K, et al. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell. 2006;124:343-54 pubmed
    ..Our findings provide a first glimpse at the complex biochemical niche of Dicer and suggest that competition exists between DCR-1-mediated small-RNA pathways. ..