Gene Symbol: eri-1
Description: 3'-5' exonuclease eri-1;Enhanced RNAI (RNA interference)
Alias: 3'-5' exonuclease eri-1;Enhanced RNAI (RNA interference)
Species: Caenorhabditis elegans

Top Publications

  1. Kennedy S, Wang D, Ruvkun G. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature. 2004;427:645-9 pubmed
    ..Thus, ERI-1 is a negative regulator that may normally function to limit the duration, cell-type specificity or endogenous functions of RNA interference. ..
  2. Gabel H, Ruvkun G. The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat Struct Mol Biol. 2008;15:531-3 pubmed publisher
    ..8S ribosomal RNA in both C. elegans and S. pombe. In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference. ..
  3. Pavelec D, Lachowiec J, Duchaine T, Smith H, Kennedy S. Requirement for the ERI/DICER complex in endogenous RNA interference and sperm development in Caenorhabditis elegans. Genetics. 2009;183:1283-95 pubmed publisher
  4. Sawyer J, Glass S, Li T, Shemer G, White N, Starostina N, et al. Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans. Genetics. 2011;188:549-64 pubmed publisher
    ..Our results implicate new genes in C. elegans gastrulation, and they show that an RNAi-based enhancer screen in C. elegans can be used as an efficient means to identify important but redundant or partially redundant developmental genes. ..
  5. Thivierge C, Makil N, Flamand M, Vasale J, Mello C, Wohlschlegel J, et al. Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi. Nat Struct Mol Biol. 2011;19:90-7 pubmed publisher
    ..Our results implicate tudor proteins in the recruitment of RdRP complexes to specific steps within DCR-1-dependent and DCR-1-independent endo-RNAi pathways. ..
  6. Duchaine T, Wohlschlegel J, Kennedy S, Bei Y, Conte D, Pang K, et al. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell. 2006;124:343-54 pubmed
    ..Our findings provide a first glimpse at the complex biochemical niche of Dicer and suggest that competition exists between DCR-1-mediated small-RNA pathways. ..
  7. Chapin A, Correa P, Maguire M, Kohn R. Synaptic neurotransmission protein UNC-13 affects RNA interference in neurons. Biochem Biophys Res Commun. 2007;354:1040-4 pubmed
    ..There is no evidence for altered neurotransmission in eri-1 mutants. ..
  8. Asikainen S, Storvik M, Lakso M, Wong G. Whole genome microarray analysis of C. elegans rrf-3 and eri-1 mutants. FEBS Lett. 2007;581:5050-4 pubmed
    ..These results provide additional support for the hypothesis that RRF-3 and ERI-1 act together in the endo-siRNA pathway, and furthermore suggests their involvement in additional biological processes. ..
  9. Armstrong K, Chamberlin H. Coordinate regulation of gene expression in the C. elegans excretory cell by the POU domain protein CEH-6. Mol Genet Genomics. 2010;283:73-87 pubmed publisher
    ..This work suggests that a role for POU-III factors in renal organs is to coordinate the expression of a set of functionally related genes. ..

More Information


  1. Mendel J, Heinecke K, Fyrst H, Saba J. Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans. J Biol Chem. 2003;278:22341-9 pubmed
    ..Our results show that sphingosine phosphate lyase is an essential gene in C. elegans and suggest that the sphingolipid degradative pathway plays a conserved role in regulating animal development. ..
  2. Legendre J, Campbell Z, Kroll Conner P, Anderson P, Kimble J, Wickens M. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. J Biol Chem. 2013;288:2532-45 pubmed publisher
    ..These studies define a set of 418 likely STAU-1 mRNA targets. Finally, we demonstrate that stau-1 mutants enhance exogenous RNAi and that stau-1;eri-1 double mutants exhibit sterility and synthetic germ line defects. ..
  3. Saharia K, Kumar R, Gupta K, Mishra S, Subramaniam J. Reserpine requires the D2-type receptor, dop-3, and the exoribonuclease, eri-1, to extend the lifespan in C. elegans. J Biosci. 2016;41:689-695 pubmed
    ..This suggests that dop-3 and eri-1 act in independent parallel pathways for RMLE and these two pathways are essential and sufficient for the longevity enhancement by reserpine in C. elegans. ..