Gene Symbol: end-3
Description: ENDoderm determining
Alias: ENDoderm determining
Species: Caenorhabditis elegans
Maduro M, Lin R, Rothman J. Dynamics of a developmental switch: recursive intracellular and intranuclear redistribution of Caenorhabditis elegans POP-1 parallels Wnt-inhibited transcriptional repression. Dev Biol. 2002;248:128-42 pubmed
..Thus, a Tcf/Lef factor represses transactivation of genes in an unsignaled daughter cell by abrogating the function of a bound activator. ..
Broitman Maduro G, Maduro M, Rothman J. The noncanonical binding site of the MED-1 GATA factor defines differentially regulated target genes in the C. elegans mesendoderm. Dev Cell. 2005;8:427-33 pubmed
..Some MED targets encode transcription factors related to those that regulate mesendoderm development in other phyla, supporting the existence of an ancient metazoan mesendoderm gene regulatory network. ..
Maduro M, Broitman Maduro G, Mengarelli I, Rothman J. Maternal deployment of the embryonic SKN-1-->MED-1,2 cell specification pathway in C. elegans. Dev Biol. 2007;301:590-601 pubmed
Maduro M, Hill R, Heid P, Newman Smith E, Zhu J, Priess J, et al
. Genetic redundancy in endoderm specification within the genus Caenorhabditis. Dev Biol. 2005;284:509-22 pubmed
..of the endoderm precursor, the E cell, in Caenorhabditis elegans requires a genomic region called the Endoderm Determining Region (EDR)...
Raj A, Rifkin S, Andersen E, van Oudenaarden A. Variability in gene expression underlies incomplete penetrance. Nature. 2010;463:913-8 pubmed publisher
..Our results demonstrate that mutations in developmental networks can expose otherwise buffered stochastic variability in gene expression, leading to pronounced phenotypic variation. ..
Sawyer J, Glass S, Li T, Shemer G, White N, Starostina N, et al
. Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans. Genetics. 2011;188:549-64 pubmed publisher
..Our results implicate new genes in C. elegans gastrulation, and they show that an RNAi-based enhancer screen in C. elegans can be used as an efficient means to identify important but redundant or partially redundant developmental genes. ..
Boeck M, Boyle T, Bao Z, Murray J, Mericle B, Waterston R. Specific roles for the GATA transcription factors end-1 and end-3 during C. elegans E-lineage development. Dev Biol. 2011;358:345-55 pubmed publisher