Gene Symbol: end 1
Description: ENDoderm determining
Alias: ENDoderm determining
Species: Caenorhabditis elegans
Maduro M, Hill R, Heid P, Newman Smith E, Zhu J, Priess J, et al
. Genetic redundancy in endoderm specification within the genus Caenorhabditis. Dev Biol. 2005;284:509-22 pubmed
..of the endoderm precursor, the E cell, in Caenorhabditis elegans requires a genomic region called the Endoderm Determining Region (EDR)...
Shoichet S, Malik T, Rothman J, Shivdasani R. Action of the Caenorhabditis elegans GATA factor END-1 in Xenopus suggests that similar mechanisms initiate endoderm development in ecdysozoa and vertebrates. Proc Natl Acad Sci U S A. 2000;97:4076-81 pubmed
..These results suggest that GATA factors may function sequentially to regulate endoderm differentiation in both protostomes and deuterostomes. ..
Broitman Maduro G, Maduro M, Rothman J. The noncanonical binding site of the MED-1 GATA factor defines differentially regulated target genes in the C. elegans mesendoderm. Dev Cell. 2005;8:427-33 pubmed
..Some MED targets encode transcription factors related to those that regulate mesendoderm development in other phyla, supporting the existence of an ancient metazoan mesendoderm gene regulatory network. ..
Witze E, Field E, Hunt D, Rothman J. C. elegans pur alpha, an activator of end-1, synergizes with the Wnt pathway to specify endoderm. Dev Biol. 2009;327:12-23 pubmed publisher
..These findings imply that PLP-1 acts as a transcriptional activator of end-1 expression that may be modulated by MAPK signaling to promote endoderm development. ..
Rawson R, Yam L, Weimer R, Bend E, Hartwieg E, Horvitz H, et al
. Axons degenerate in the absence of mitochondria in C. elegans. Curr Biol. 2014;24:760-5 pubmed publisher
..Thus, mitochondria are not required for axon degeneration and serve a protective role in C. elegans axons. ..
Zhu J, Fukushige T, McGhee J, Rothman J. Reprogramming of early embryonic blastomeres into endodermal progenitors by a Caenorhabditis elegans GATA factor. Genes Dev. 1998;12:3809-14 pubmed
..This suggests that a primary function of these maternal factors is to regulate zygotic end-1 expression, which is then sufficient to initiate the entire program for endoderm development. ..
Boeck M, Boyle T, Bao Z, Murray J, Mericle B, Waterston R. Specific roles for the GATA transcription factors end-1 and end-3 during C. elegans E-lineage development. Dev Biol. 2011;358:345-55 pubmed publisher