Gene Symbol: emb-4
Description: hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Katic I, Greenwald I. EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans. Genetics. 2006;174:1907-15 pubmed
    ..emb-4 encodes a large nuclearly localized protein containing a predicted ATPase domain and has apparent orthologs in fission yeast, plants, and animals. ..
  2. Akay A, Di Doménico T, Suen K, Nabih A, Parada G, Larance M, et al. The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription. Dev Cell. 2017;42:241-255.e6 pubmed publisher
    ..Thus, Aquarius and HRDE-1 act as gatekeepers coordinating gene expression and genome defense. ..
  3. Tyc K, Nabih A, Wu M, Wedeles C, Sobotka J, Claycomb J. The Conserved Intron Binding Protein EMB-4 Plays Differential Roles in Germline Small RNA Pathways of C. elegans. Dev Cell. 2017;42:256-270.e6 pubmed publisher
    ..These data suggest that EMB-4 could contribute to a molecular signature that distinguishes the targets of these two germline small RNA pathways. ..