elt 1


Gene Symbol: elt 1
Description: Erythroid-Like Transcription factor family;Transcription factor elt-1
Alias: Erythroid-Like Transcription factor family;Transcription factor elt-1
Species: Caenorhabditis elegans

Top Publications

  1. Smith J, McGarr P, Gilleard J. The Caenorhabditis elegans GATA factor elt-1 is essential for differentiation and maintenance of hypodermal seam cells and for normal locomotion. J Cell Sci. 2005;118:5709-19 pubmed
    ..These results suggest that elt-1 is a key regulator of neuronal function in larvae and adult worms. ..
  2. Shim Y, Bonner J, Blumenthal T. Activity of a C. elegans GATA transcription factor, ELT-1, expressed in yeast. J Mol Biol. 1995;253:665-76 pubmed
    ..We conclude that, although ELT-1 having only its C-terminal finger is capable of activation in response to the WGATAR site, the presence of the upstream finger supplies additional base specificity. ..
  3. Page B, Zhang W, Steward K, Blumenthal T, Priess J. ELT-1, a GATA-like transcription factor, is required for epidermal cell fates in Caenorhabditis elegans embryos. Genes Dev. 1997;11:1651-61 pubmed
    ..The ELT-1 protein is expressed in epidermal cells and in their precursors. We propose that elt-1 functions at an early step in the specification of epidermal cell fates. ..
  4. Baugh L, Wen J, Hill A, Slonim D, Brown E, Hunter C. Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions. Genome Biol. 2005;6:R45 pubmed
    ..Genetic interactions within a homologous set of genes involved in vertebrate myogenesis indicate broad conservation of the muscle module and suggest that other genetic modules identified in C. elegans will be conserved. ..
  5. del Castillo Olivares A, Kulkarni M, Smith H. Regulation of sperm gene expression by the GATA factor ELT-1. Dev Biol. 2009;333:397-408 pubmed publisher
    ..This work demonstrates a role for the ELT-1 transcription factor in sperm, and provides a critical link between the germ line sex determination program and gamete-specific gene expression. ..
  6. Brabin C, Appleford P, Woollard A. The Caenorhabditis elegans GATA factor ELT-1 works through the cell proliferation regulator BRO-1 and the Fusogen EFF-1 to maintain the seam stem-like fate. PLoS Genet. 2011;7:e1002200 pubmed publisher
    ..Overall, our data suggest that ELT-1 has dual roles in the stem-like seam cells, acting both to promote proliferation and prevent differentiation. ..
  7. Cohen M, Kim S, Morita K, Kim S, Han M. The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs. PLoS Genet. 2015;11:e1005099 pubmed publisher