Gene Symbol: ekl-1
Description: hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Thivierge C, Makil N, Flamand M, Vasale J, Mello C, Wohlschlegel J, et al. Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi. Nat Struct Mol Biol. 2011;19:90-7 pubmed publisher
    ..Our results implicate tudor proteins in the recruitment of RdRP complexes to specific steps within DCR-1-dependent and DCR-1-independent endo-RNAi pathways. ..
  2. Robert V, Sijen T, van Wolfswinkel J, Plasterk R. Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. Genes Dev. 2005;19:782-7 pubmed
    ..Together with molecular data also presented in this study, these results suggest that in C. elegans repetitive sequences trigger transcriptional gene silencing using RNAi and chromatin factors. ..
  3. Rocheleau C, Cullison K, Huang K, Bernstein Y, Spilker A, Sundaram M. The Caenorhabditis elegans ekl (enhancer of ksr-1 lethality) genes include putative components of a germline small RNA pathway. Genetics. 2008;178:1431-43 pubmed publisher
    ..These small RNAs and the other ekl genes likely control the expression of one or more regulators of Ras-ERK signaling that function at or near the level of kinase suppressor of Ras (KSR). ..
  4. Claycomb J, Batista P, Pang K, Gu W, Vasale J, Van Wolfswinkel J, et al. The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell. 2009;139:123-34 pubmed publisher
    ..Instead, our findings support a model in which CSR-1 complexes target protein-coding domains to promote their proper organization within the holocentric chromosomes of C. elegans. ..
  5. Andralojc K, Campbell A, Kelly A, Terrey M, Tanner P, Gans I, et al. ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans. PLoS Genet. 2017;13:e1006611 pubmed publisher