Gene Symbol: egl-38
Description: hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Chamberlin H, Palmer R, Newman A, Sternberg P, Baillie D, Thomas J. The PAX gene egl-38 mediates developmental patterning in Caenorhabditis elegans. Development. 1997;124:3919-28 pubmed
    ..elegans development and also provides the opportunity to investigate the in vivo functions of this class of PAX proteins with single cell resolution. ..
  2. Trent C, Tsuing N, Horvitz H. Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics. 1983;104:619-47 pubmed
    ..At least two of the egl mutants appear to be defective in the processing of environmental signals that modulate egg laying and may define new components of the neural circuitry that control egg laying. ..
  3. Wang X, Greenberg J, Chamberlin H. Evolution of regulatory elements producing a conserved gene expression pattern in Caenorhabditis. Evol Dev. 2004;6:237-45 pubmed
    ..elegans, with only one copy retaining the ability to regulate lin-48 in vivo. These results illustrate molecular changes that can occur despite maintenance of conserved gene function in different species. ..
  4. Rajakumar V, Chamberlin H. The Pax2/5/8 gene egl-38 coordinates organogenesis of the C. elegans egg-laying system. Dev Biol. 2007;301:240-53 pubmed
    ..As the Pax2 gene performs similar roles in the development of the mammalian kidney, we show that coordinating organogenesis is a conserved function for Pax2/5/8 transcription factors...
  5. Chamberlin H, Brown K, Sternberg P, Thomas J. Characterization of seven genes affecting Caenorhabditis elegans hindgut development. Genetics. 1999;153:731-42 pubmed
    ..Our results suggest that a combination of different factors contribute to normal C. elegans hindgut development. ..
  6. Kanteti R, El Hashani E, Dhanasingh I, Tretiakova M, Husain A, Sharma S, et al. Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer. BMC Cancer. 2014;14:185 pubmed publisher
    ..PAX8 provides signals for growth and motility of NSCLC cells and is necessary for MET and RON expression. Further investigations are necessary to investigate the therapeutic potential of PA8 in NSCLC...
  7. Zhang Y, Emmons S. Specification of sense-organ identity by a Caenorhabditis elegans Pax-6 homologue. Nature. 1995;377:55-9 pubmed
    ..Its function in this context could be to regulate the expression of cell recognition and adhesion proteins required for sense-organ assembly...
  8. Johnson A, Fitzsimmons D, Hagman J, Chamberlin H. EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis elegans organ development. Development. 2001;128:2857-65 pubmed
    ..These experiments demonstrate a functional link between Pax and Ovo transcription factors, and provide a model for how Pax transcription factors can regulate different target genes in different cells. ..
  9. Fitzsimmons D, Lutz R, Wheat W, Chamberlin H, Hagman J. Highly conserved amino acids in Pax and Ets proteins are required for DNA binding and ternary complex assembly. Nucleic Acids Res. 2001;29:4154-65 pubmed
    ..Moreover, the data suggest that interactions between Pax and Ets proteins are an important mechanism that regulates fundamental biological processes in worms and humans. ..

More Information


  1. Zhang G, Sleiman S, Tseng R, Rajakumar V, Wang X, Chamberlin H. Alteration of the DNA binding domain disrupts distinct functions of the C. elegans Pax protein EGL-38. Mech Dev. 2005;122:887-99 pubmed
    ..The distinction between DNA binding and activity is consistent with the model that other factors commonly play a role in mediating Pax protein target site selection and function in vivo. ..
  2. Park D, Jia H, Rajakumar V, Chamberlin H. Pax2/5/8 proteins promote cell survival in C. elegans. Development. 2006;133:4193-202 pubmed
    ..elegans bcl-2 gene. These results identify a mechanism for Pax2/5/8-mediated regulation of cell death, and underscore the importance of transcriptional regulation of core apoptotic pathway genes in influencing cell survival. ..
  3. Fernandes J, Sternberg P. The tailless ortholog nhr-67 regulates patterning of gene expression and morphogenesis in the C. elegans vulva. PLoS Genet. 2007;3:e69 pubmed
    ..We postulate that the differential levels and combinatorial patterns of lin-11, cog-1, and nhr-67 expression are a part of a regulatory code for the mature vulval cell types...